Search for dissertations about: "11-cis retinol"

Found 5 swedish dissertations containing the words 11-cis retinol.

  2. 1. The molecular biology of retinoid metabolism : identification of an 11-cis retinol dehydrogenase in the retinal pigment epithelium

    Author : András Simon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 11-cis retinol; 11-cis retinol dehydrogenase; chromophore; 11-cis retinaldehyde; 9-cis retinol; 9-cis retinol dehydrogenase; retinal pigment epithelium; vitamin A; short-chain alcohol dehydrogenase;

    Abstract : Vitamin A derivatives (retinoids) are essential molecules in the course of embryonic development, postnatal growth and adult physiology. The physiological functions of retinoids are thought to be mediated mainly by retinoic acid which regulates the expression of various genes, and 11-cis retinaldehyde, which is the common chromophore of visual pigments. READ MORE

  4. 2. Retinol dehydrogenases in retinoid metabolism : studies on a 9-cis/11-cis-retinol dehydrogenase in adult and embryonic tissues

    Author : Anna Romert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Retinoids (vitamin A derivatives) are necessary for normal embryonic development and in the adult, for vision, differentiation of various epithelia, reproduction and in the immune system. The physiological effects of retinoids are mediated by binding to the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). READ MORE

  5. 3. Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse

    Author : Paulina Tuvendal; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; -; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : Retinoids are needed in the embryo to ensure proper development and in the adult forvision, maintenance of epithelia and sperm production. Retinol is oxidised within the cell generating retinal and, irreversibly, retinoic acid. READ MORE

  6. 4. Retinoid processing in vivo : characterization and structure-function analysis of retinol dehydrogenases

    Author : Kristian Tryggvason; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Retinol; vitamin A; retinol dehydrogenase; reporter assay;

    Abstract : Retinoids (vitamin A derivatives) are vital nutrients that regulate a variety of physiological processes, including embryonic development, postnatal growth, reproduction, cell differentiation as well as maintenance of the immune system and vision. Most of the physiological functions of retinoids are believed to be controlled by retinoic acid (RA) altered gene expression via two classes of nuclear hormone receptors, the RARs and RXRs. READ MORE

  7. 5. Molecular aspects of retinol uptake and activation

    Author : Martin Lidén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. 11-Cis-retinal serves as the chromophore of the visual pigments in the retina, whereas the hormonal retinoids, all-trans and 9-cis retinoic acid (RA), regulate the non-visual functions via activation of nuclear retinoid receptors (RARs and RXRs). READ MORE