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Showing result 1 - 5 of 39 swedish dissertations matching the above criteria.

  2. 1. EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy : Preclinical Studies

    Author : Erika Nordberg; Bengt Glimelius; Jörgen Carlsson; Lars Gedda; Bo Stenerlöw; Vladimir Tolmachev; Peter Bernhardt; Uppsala universitet; []
    Keywords : Biomedicine; EGFR; HER2; affibody molecule; tumour targeting; 125I; 111In; Biomedicin;

    Abstract : The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting the surrounding tissue. One promising approach is to use radiolabelled molecules to target receptors that are overexpressed in cancer cells. READ MORE

  4. 2. Therapy with 177Lu-octreotate - pharmacokinetics, dosimetry and kidney toxicity

    Author : Maria Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; 177Lu-octreotate; 111In-octreotide; dosimetry; biokinetics; scintigraphy; conjugate view method; renal function; renal toxicity; lysine; DMSA; 99mTc-DTPA; 99mTc-DMSA;

    Abstract : 177Lu-octreotate is used for treatment of patients with somatostatin receptor expressing neuroendocrine tumors in some clinics using a standard schedule. Renal and bone marrow toxicity are the main limiting factors. READ MORE

  5. 3. Activity quantification based on scintillation camera imaging - Application to 111In/90Y radioimmunotherapy

    Author : David Minarik; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunotherapy; bremsstrahlung imaging; activity quantification; SPECT; conjugate view; Yttrium;

    Abstract : Radionuclide therapy (RNT), is important for the treatment of certain benign and malignant diseases. 90Y-Zevalin™ therapy has become an established method of treating patients with non-Hodgkin B-cell lymphoma. READ MORE

  6. 4. Pharmacokinetics and dosimetry of radiolabelled octreotide for tumour therapy

    Author : Peter Bernhardt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; radiation dosimetry; therapy; radionuclides; octreotide; neuroendocrine tumours; nude mice; patients;

    Abstract : Somatostatin (SS) receptors (sstr) are usually highly expressed on neuroendocrine (NE) tumours. The radiolabelled SS analogue 111In-DTPA-D-Phe1-octreotide is today widely used to scintigraphically visualise NE tumours, and high 111In activity concentrations are obtained in tumour vs. normal tissues. READ MORE

  7. 5. Site-specific labeling of affinity molecules for in vitro and in vivo studies

    Author : Anna Perols; Amelie Eriksson Karlström; Christian Hackenberger; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; molecular imaging; site-specific labeling; solid phase peptide synthesis; IgG-binding domains; photoconjugation.; Bioteknologi; Biotechnology;

    Abstract : The thesis is focused on site-specific labeling of affinity molecules for different applications where two types of binding proteins, Affibody molecules and antibodies, have been used. For the purpose of improving the properties of Affibody molecules for in vivo imaging, novel bi-functional chelators for radiolabeling using the radionuclide 111In were evaluated. READ MORE