Search for dissertations about: "111In"

Showing result 16 - 20 of 39 swedish dissertations containing the word 111In.

  2. 16. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Author : Anna-Karin Haylock; Marika Nestor; Göran Laurell; Matti Anniko; Katrine Riklund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Abstract : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. READ MORE

  4. 17. Radiobiological studies with low energy ionizing radiation - dosimetric aspects

    Author : Gustav Grafström; Lund Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; low energy; Radiobiology; dosimetry; cell model; Radiofarmaceutisk teknik; Radiopharmaceutical technology; radiobiologi; Nukleärmedicin; radiobiology; Nuclear medicine; animal model;

    Abstract : Background: During the last 20 years both in vitro and in vivo models have been developed for studies of the cell killing characteristics of low energy electrons, e.g. Auger electrons. This thesis deals with radiobiological effects of radiation from indium isotopes in V79 cells in vitro (Paper I-III) and the rat testis in vivo (Paper IVV). READ MORE

  5. 18. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications

    Author : Mikaela Friedman; Stefan Ståhl; Fredrik Nilsson; James S. Huston; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; affinity maturation; phage display selection; EGFR; molecular imaging; protein engineering; tumor targeting; Bioengineering; Bioteknik;

    Abstract : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. READ MORE

  6. 19. Brain distribution of a bispecific antibody targeting Aβ

    Author : Gustavsson Tobias; Dag Sehlin; Stina Syvänen; Paul O'Callaghan; Danica Stanimirovic; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; blood-brain barrier; single-photon emission computed tomography SPECT ; bispecific antibody; immunotherapy; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Abstract : Alzheimer’s disease (AD) is characterised by aberrant protein aggregation in the brain with subsequent synaptic loss, neuroinflammation, and brain atrophy that ultimately clinically manifests as cognitive impairment. Histopathological findings in AD are extracellular plaques of the protein amyloid-beta (Aβ), Aβ in blood vessels (CAA), and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau. READ MORE

  7. 20. Radionuclide targeting with particular empahsis on urinary bladder carcinoma

    Author : Anna Sjöström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : The incidence of urinary bladder carcinoma is increasing and many patients die every year of this disease despite assumed radical therapy. Thus, there is a need for improved methods of diagnosis and therapy. READ MORE