Search for dissertations about: "111In"

Showing result 6 - 10 of 39 swedish dissertations containing the word 111In.

  2. 6. Therapy of neuroendocrine tumors with 177Lu-octreotate - Human tumor cell types and models and optimization of treatment : Terapi av neuroendokrina tumörer med 177Lu-octreotate

    Author : Johanna Dalmo; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; somatostatin; radionuclide therapy; receptor up-regulation; RBP; nephrotoxicity;

    Abstract : Neuroendocrine (NE) tumors (NET) have often metastasized at the time of diagnose, which makes it hard to cure patients with NET. Radiolabeled hormone analogues (especially somatostatin analogues, SS) can be used for diagnostics (e.g. 111In-octreotide) and therapy (e. READ MORE

  4. 7. Intraoperative scintigraphic detection of abdominal endocrine tumors : Development and evaluation of hand held gamma sensitive probes for¹¹¹In

    Author : Ulf Öhrvall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Adrenocortical carcinoma; endocrine pancreatic tumors; mid-gut carcinoids; intraoperative gammadetection; octreotide; scintigraphy; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Surgery of endocrine tumors benefit from accurate pre and- intraoperative localization methods,and scintigraphy has become an important contribution in this respect. In the present thesis therequisites for scintigraphic localization of abdominal endocrine tumors and new detectors forintraoperative gammadetection are evaluated. READ MORE

  5. 8. Tumour Targeting Using Radiolabelled EGF Conjugates : Preclinical Studies

    Author : Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; Radiation biology; Strålningsbiologi;

    Abstract : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. READ MORE

  6. 9. RADIOIMMUNOTHERAPY & EXTRACORPOREAL ADSORPTION Preclinical Studies of the Pharmacokinetics & Biotinylation of Radioimmunoconjugates in Immunocompetent Rats

    Author : Zhongmin Wang; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; oncology; cancerology; Cytologi; Cytology; extracorporeal adsorption; tri-functional chelator; maximal tolerable dose; biotin; intraperitoneal administration; biodistribution; pharmacokinetics; biotinylation; radiolabeling; rat; monoclonal antibody; radionuclide;

    Abstract : Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcinomas. READ MORE

  7. 10. Theranostic Targeting of GRPR and PSMA in Prostate Cancer

    Author : Ayman Abouzayed; Anna Orlova; Ulrika Rosenström; Anzhelika Vorobyeva; Bogdan Mitran; Cristina Müller; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; gastrin-releasing peptide receptor GRPR ; prostate-specific membrane antigen PSMA ; nuclear medicine; molecular imaging; radiotracers; theranostics; Farmaceutisk vetenskap; Pharmaceutical Science; Oncology; Onkologi;

    Abstract : This thesis is based on five original articles that investigated the theranostics of prostate cancer by gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) targeting. GRPR and PSMA are two extensively evaluated prostate cancer cell markers due to their overexpression in the majority of prostate cancer samples. READ MORE