Search for dissertations about: "11C-PIB"

Found 5 swedish dissertations containing the word 11C-PIB.

  1. 1. Methodological aspects of quantitative cardiac molecular imaging

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tanja Kero; Mark Lubberink; Håkan Ahlström; Elin Trägårdh; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; cardiac amyloidosis; 11C-PIB; retention index; standardized uptake value; PET-MR; MRI; myocardial blood flow; 15O-water; quantification; quantitative modeling;

    Abstract : The objective of this research was to facilitate the use of quantitative cardiac molecular imaging by developing and validating methods and applications. More specifically:we determined the optimal tracer kinetic model for analysis of 11C-PIB and evaluated the performance of two simpler measures, retention index (RI) and standardized uptake value (SUV), in the quantification of cardiac 11C-PIB uptake in amyloidosis. READ MORE

  2. 2. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Ahmadul Kadir; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; cholinesterase inhibitors; positron emission tomography; nicotinic acetylcholine receptor; acetylcholinesterase; multi-tracer; 11C-nicotine; 11C-PMP; 18F-FDG; 11C-PIB; donepezil; rivastigmine; galantamine; phenserine.;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. READ MORE

  3. 3. Amyloid imaging in Alzheimer´s disease and mild cognitive impairment by Positron Emission Tomography

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Anton Forsberg; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Effectiveness of future treatment strategies in Alzheimer s disease (AD) will rely on early detection of disease and the possibility to clearly evaluate their effects. The findings presented in this thesis concerns both early in vivo detection of amyloid deposition in the brains of patients at risk of developing AD and the longitudinal changes of pathological and functional parameters in patients with AD. READ MORE

  4. 4. Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers

    University dissertation from Stockholm : Karolinska Institutet, Dept of Neurobiology, Care Sciences and Society

    Author : Antoine Leuzy; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in concert, these protein opathies lead to the loss of synapses and neurons (neurodegeneration). READ MORE

  5. 5. Molecular imaging of tau in the pathological cascade of Alzheimer’s disease

    University dissertation from Stockholm : Karolinska Institutet, Dept of Neurobiology, Care Sciences and Society

    Author : Konstantinos Chiotis; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The pathology of Alzheimer’s disease (AD) is characterised by the misfolding and aggregation of amyloid-β (Aβ) into extracellular plaques and aggregation of tau into intracellular neurofibrillary tangles. Recent advances in molecular imaging have allowed the development of positron emission tomography (PET) tracers for the in vivo detection of Aβ plaques while current efforts focus on the evaluation of recently proposed tracers targeting tau pathology. READ MORE