Search for dissertations about: "11beta-hydroxysteroid dehydrogenase type 1"

Found 5 swedish dissertations containing the words 11beta-hydroxysteroid dehydrogenase type 1.

2. 1. 11beta-Hydroxysteroid dehydrogenase type 1 as a pharmacological target in metabolic disease

   Author : Malin Hult; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The metabolic syndrome is a collection of associated disorders, affected by lifestyle, genetic predisposition and environment, and emerges as a consequence of the Western society lifestyle. It describes a variety of cardiovascular and atherosclerotic risk factors including insulin resistance, obesity, dyslipidemia and arterial hypertension. READ MORE

4. 2. Brain function and glucocorticoids in obesity and type 2 diabetes including effects of lifestyle interventions

   Author : Andreas Stomby; Tommy Olsson; Mats Ryberg; Carl-Johan Boraxbekk; Alasdair MacLullich; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; glucocorticoid; cortisol; 11beta hydroxysteroid dehydrogenase type 1; episodic memory; functional magnetic resonance imaging; paleolithic diet; exercise; Internal Medicine; invärtesmedicin; medicin; Medicine;

   Abstract : Background Obesity and associated metabolic dysregulation are linked to impaired cognitive function and alterations in brain structure, which increases the risk of age-related dementia. Increased glucocorticoid (GC) exposure may be a potential mediator of these negative effects on the brain. READ MORE

5. 3. Congenital adrenal hyperplasia, CYP21 deficiency, screening and clinical aspects

   Author : Anna Nordenström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Congenital adrenal hyperplasia; 21 -hydroxylase deficiency; CYP21; neonatal screening; 17-OHP; sex-typed behavior; toy play.;

   Abstract : Congenital adrenal hyperplasia (CAH) is a group of recessively inherited disorders. More than 90% of all cases of CAB are caused by 21-hydroxylase deficiency. This enzyme deficiency results in reduced ability to synthesize cortisol and aldosterone and at the same time increased secretion of androgens. READ MORE

6. 4. The metabolic syndrome : studies on thrifty genes

   Author : Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

   Abstract : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. READ MORE

7. 5. Expression and purification of membrane proteins: Focus on the G-protein coupled receptor MC4r

   Author : Viveka Dolby; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzymology; Proteiner; enzymologi; Proteins; melanocortin 4 receptor; GPCR; purification; Expression; membrane proteins;

   Abstract : Membrane proteins are crucial components of the cell and are involved in many biological processes. Recombinant overexpression systems together with different purification methods are necessary to obtain large amounts of purified receptor for biophysical and functional studies. READ MORE