Search for dissertations about: "125I"

Showing result 1 - 5 of 27 swedish dissertations containing the word 125I.

  1. 1. EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy Preclinical Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erika Nordberg; Bengt Glimelius; Jörgen Carlsson; Lars Gedda; Bo Stenerlöw; Vladimir Tolmachev; Peter Bernhardt; [2008]
    Keywords : Biomedicine; EGFR; HER2; affibody molecule; tumour targeting; 125I; 111In; Biomedicin;

    Abstract : The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting the surrounding tissue. One promising approach is to use radiolabelled molecules to target receptors that are overexpressed in cancer cells. READ MORE

  2. 2. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Winander; Lars Baltzer; Stefan Sjöberg; Jörgen Carlsson; Vladimir Tolmachev; Thomas Schrader; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carborane; doxorubicin; 125I; molecular recognition; four-helix bundle; polypeptide conjugate; affinity; chitinase; acetylcholine esterase; Organisk kemi;

    Abstract : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. READ MORE

  3. 3. Interaction of Triglyceride-rich Lipoproteins with Platelets and Vitamin K-dependent Coagulation Factors

    University dissertation from Department of Internal Medcine, University Hospital of Lund

    Author : Ning Xu; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglycerides.; Prothrombin; Protein S; Protein C; Platelets; Phospholipids; Metabolism; Lipoproteins; Lipids; Endocytosis; Electron microscopy; Cytochemistry; Coronary heart disease; Blood coagulation factors; Arachidonic acid; Atherosclerosis; Clinical chemistry; Klinisk kemi; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : 1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. READ MORE

  4. 4. Improving radioimmunotargeting of tumors : the impact of extracorporeal immunoadsorption and preload in rats

    University dissertation from Department of Internal Medcine, University Hospital of Lund

    Author : Michael Garkavij; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytology; preload.; immunoadsorption; MAb; rat; Tumor; radioimmunotargeting; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : In radioimmunotherapy of tumors, uptake of the monoclonal antibody (MAb) used is often too low in relation to its uptake in normal tissues. The purpose of these studies was to improve experimental tumor radioimmunotargeting with (a) extracorporeal immunoadsorption (ECIA), where excess of radiolabeled MAbs circulating in blood is removed, (b) or by preload with unlabeled MAb prior to injection of radiolabeled MAb, (c) or by a combination of these. READ MORE

  5. 5. The optic tectum of the salmon:site of interaction of neurohormonal photoperiodic and neural visual signals. The GABAergic neuronal system and melatonin receptors

    University dissertation from Department of Zoology, Lund University

    Author : Marie Anzelius; [1998]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Animal anatomy; melatonin receptors; GABA; optic tectum; fish; brain; animal morphology; Djurs anatomi och morfologi;

    Abstract : Melatonin is a neurohormone which mediates photoperiodic signals from the pineal organ to the brain. GABA (g-aminobutyric acid) is the major inhibitory transmitter in the central nervous system. READ MORE