Search for dissertations about: "14-3-3 Proteins"

Showing result 11 - 15 of 21 swedish dissertations containing the words 14-3-3 Proteins.

  2. 11. Regulation of CDK dephosphorylation in mitotic entry

    Author : Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. READ MORE

  4. 12. Proteome profiling of human breast cancer

    Author : Olena Zakharchenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer (BC) takes thousands of woman’s lives yearly. Several factors have been found to influence initiation and development of breast cancer, and to affect prognosis and treatment of this disease. READ MORE

  5. 13. Lysosomal Membrane Stability and Cathepsins in Cell Death

    Author : Hanna Appelqvist; Karin Öllinger; Katarina Kågedal; Petra Wäster; Maria Shoshan; Linköpings universitet; []
    Keywords : ;

    Abstract : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. READ MORE

  6. 14. Biochemical and Structural Studies on the Adaptor Protein p130Cas

    Author : Fariborz Nasertorabi; Kathryn R Ely; Lars Liljas; Jyrki Heino; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Integrin signaling; p130Cas; X-ray Crystallography; NMR Spectroscopy; Protein phosphorylation; BCAR-1; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. READ MORE

  7. 15. Protein kinases in hormonal regulation of adipocyte metabolism

    Author : Christine Berggreen; Proteinfosforylering; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Abstract : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. READ MORE