Search for dissertations about: "14-3-3 Proteins"
Showing result 16 - 20 of 21 swedish dissertations containing the words 14-3-3 Proteins.
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16. Organization of signaling networks during receptor-mediated membrane protein trafficking
Abstract : The mechanisms by which receptor signals are organized in a synergic/hierarchical manner in time and space during regulation of integral membrane protein traffic remain a present challenge. The aim of this study was to address some critical aspects of these processes. READ MORE
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17. LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
Abstract : Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. READ MORE
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18. Cell cycle regulation in cancer: A noncoding perspective
Abstract : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. READ MORE
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19. The role of the RNA-binding protein Wig-1 in post-transcriptional regulation of gene expression
Abstract : The p53 transcription factor is activated by cellular stress. This triggers transcriptional activation of a number of p53 target genes, leading to responses such as cell cycle arrest and/or induction of apoptosis. Wig-1 is a p53 target gene and its RNA and protein levels increase after p53 protein activation. READ MORE
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20. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease
Abstract : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. READ MORE