Search for dissertations about: "2- pyrimidine"

Showing result 1 - 5 of 28 swedish dissertations containing the words 2- pyrimidine.

  1. 1. Physicochemical and Structural Aspects of Nucleic Acids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Subhrangsu Chatterjee; Adolf Gogoll; Helena Grennberg; Göran Widmalm; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; pKa; Hydrogen bonding; Stacking; NMR; MD; DNA; RNA; Pyrimidine; Organisk kemi;

    Abstract : This thesis consists of seven research publications concerning (i) pKa studies of nucleobases in model nucleotides to understand why RNA duplexes are more stable than DNA duplexes (Paper I), (ii) the role of Me(T)-π interactions in the relative stability of DNA-RNA heteroduplexes (Paper II), (iii) pKa measurements in nucleotides with different 2′-substituents (paper III), (iv) a conformation study of constrained sugars and a pKa study of 1-thyminyl to reveal effect of sugar constraints on the pKa of the nucleobase (paper IV), (v) NMR and MD studies of 1′, 2′-oxetane constrained thymidine incorporated Dickerson Drew dodecamer (paper V), (vi) the sequence dependent pKa perturbation of 9-guaninyl moeity in single stranded (ss) DNA and RNA (paper VI), (vii) the non identical chemical nature of internucleotidic phosphates in (ss) RNA using 31P NMR (paper VI), and an alkaline hydrolysis study of phosphodiesters in ssRNAs (paper VII). The architecture of DNA and RNA molecules is determined by (a) hydrogen bonding (b) base stacking (c) a variety of additional non-covalent interactions. READ MORE

  2. 2. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda Åkerbladh; Mats Larhed; Luke Odell; Anders Karlén; Lise-Lotte Gundersen; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Carbonylation; Multicomponent reactions; Domino reactions; Heterocycles; 4-Quinolones; 2-Aminoquinazolinones; Benzoxazinones; N-Acylguanidines; Type II NADH dehydrogenase; NDH-2;

    Abstract : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. READ MORE

  3. 3. Multiconfigurational perturbation theory

    University dissertation from Lund

    Author : Kerstin Andersson; [1992]
    Keywords : Electron correlation; CASSCF; multiconfigurational second-order perturbation theory; CASPT2; ozone; C; N; O; F; Si; P; S; Cl; Ni; benzene; pyridine; pyrazine; pyrimidine; pyridazine; s-triazine; electric properties; excited states; spectroscopic data;

    Abstract : The aim of the thesis is to analyze a method which describes the electron correlation in atoms and molecules. The method is based on Rayleigh-Schrödinger perturbation theory with a partitioning of the Hamiltonian into a fairly simple zeroth-order operator and a perturbation operator. READ MORE

  4. 4. Temperature effects on UV-B induced DNA damage and repair in plants and a lichen

    University dissertation from Markus Paulsson, Sölvegatan 35, SE-223 62 Lund, Sweden

    Author : Markus Paulsson; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tobacco Nicotiana tabacum ; Temperature; Subarctic; Plants; Photoreactivation; Photolyase; Lichen; DNA damage; Cyclobutane pyrimidine dimers CPD ; 6-4 Photoproducts; Cladonia arbuscula ssp. mitis; Ultraviolet radiation; UV-B; Vaccinium vitis-idaea; Plant genetics; Växtgenetik;

    Abstract : All living organisms have DNA and since DNA is essential to life it must be repaired when damaged. UV radiation is one of the major DNA damaging agents, which photosynthetic organisms cannot avoid. READ MORE

  5. 5. Studies of enzymes in mitochondrial DNA precursor synthesis : regulatory mechanisms for human thymidine kinase 2 and deoxyguanosine kinase

    University dissertation from ; Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences

    Author : Ren Sun; Sveriges lantbruksuniversitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : As important enzymes in mitochondrial nucleotide salvage pathway, thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) are expressed constitutively in almost all cells. These two enzymes catalyze the initial rate-limiting phosphorylation of pyrimidine and purine deoxynucleosides, respectively, providing DNA precursors for mitochondrial DNA (mtDNA) replication. READ MORE