Search for dissertations about: "2-Arachidonoylglycerol"

Found 5 swedish dissertations containing the word 2-Arachidonoylglycerol.

2. 1. Bioactive Lipids in Nociception

   Author : Anna Ermund; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : Cannabinoids; Anandamide; AM404; 2-Arachidonoylglycerol; Acetaminophen; Cyclooxygenase; Nocicieption; TRPV1;

   Abstract : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. READ MORE

4. 2. The role of cannabinoid receptors, G alpha z, and B cell receptor in lymphoma pathobiology with focus on chemotaxis

   Author : Magali Merrien; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia (CLL) are two incurable B cell malignancies, with an overall survival of 5 to 8 years and 6 to 10 years, respectively. Therapies are available but are often very aggressive, and patients relapse due to minimal residual disease. READ MORE

5. 3. Endocannabinoids and Related Lipids in Chronic Pain : Analytical and Clinical Aspects

   Author : Niclas Stensson; Bijar Ghafouri; Björn Gerdle; Nazdar Ghafouri; Christopher Fowler; Per-Johan Jakobsson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : In Europe, approximately one in five adults experience chronic pain, pain that lasts more than three months. Chronic pain is a significant problem not only for those people suffering from chronic pain but also for society. The prevalence of chronic pain is higher in women and lower socioeconomic groups. READ MORE

6. 4. In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides

   Author : Joanne Bakker; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, helping neurons to mature and neuronal circuits to take form. READ MORE

7. 5. Endocannabinoid metabolism : the impact of inflammatory factors and pharmacological inhibitors

   Author : Jessica Karlsson; Christopher Fowler; Stig Jacobsson; Jürg Gertsch; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

   Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE