Search for dissertations about: "2-nitrofluorene"

Found 3 swedish dissertations containing the word 2-nitrofluorene.

2. 1. Studies on DNA adducts and carcinogenesis with 2-nitrofluorene as a model substance

   Author : Xian-Shu Cui; Karolinska Institutet; Karolinska Institutet; []
   Keywords : 2-nitrofluorene; carcinogens; DNA adducts; preneoplastic lesion; tumor;

   Abstract : A number of carcinogens or their electrophilic intermediates are able to bind covalently to DNA, forming DNA adducts. DNA adducts may cause gene mutations if they are misrepaired or remain unrepaired before DNA replication occurs. DNA adduct formation is believed to be the initial step of chemical carcinogenesis. READ MORE

4. 2. Aspects of the regulation of human sperm motility

   Author : Pär K G Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In this thesis I address some of the possible causes for oligozoospermia and low sperm motility, two factors that, singly or in combination, are often seen in cases of male subfertility. In the first study we evaluated the effect on human spermatozoa of the toxicity of compounds present in diesel exhaust. READ MORE

5. 3. High-performance liquid chromatography for analysis of 32P-postlabeled DNA adducts

   Author : Magnus Zeisig; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA adducts; 32P-postlabeling; HPLC; method development;

   Abstract : The formation of DNA adducts, i.e. the covalent binding of chemicals and chemical groups to DNA, is believed to be an important step in chemical carciogenesis. DNA adducts are usually formed at very low levels which requires very sensitive methods to analyze them. READ MORE