Search for dissertations about: "2-pyridone"

Showing result 1 - 5 of 10 swedish dissertations containing the word 2-pyridone.

  1. 1. Development of 2-Pyridone-based central fragments Affecting the aggregation of amyloid proteins

    University dissertation from Umeå, Sweden : Umeå universitet

    Author : Magnus Sellstedt; Umeå universitet.; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; central fragment alteration; multi-component reactions; directed diversity-oriented synthesis; peptidomimetics; amyloid; protein aggregation; pilicide; curlicide; Biorganic Chemistry; bioorganisk kemi;

    Abstract : There are many applications of small organic compounds, e.g. as drugs or as tools to study biological systems. Once a compound with interesting biological activity has been found, medicinal chemists typically synthesize small libraries of compounds with systematic differences to the initial “hit” compound. READ MORE

  2. 2. Application of the 2-Pyridone Hydrogen-Bonding Motif in Supramolecular Catalysis and in Phenanthroline Based Ligands

    University dissertation from Organic Chemistry, Lund University

    Author : Stefan Jonsson; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; X-ray crystallography; Phenanthroline; Supramolecular Catalysis; Jacobsen-Katsuki Epoxidation; Mn salen ; Hydrogen-bonding; Supramolecular Chemistry; 2-Pyridone; Organisk kemi;

    Abstract : This thesis concentrates on the development, synthesis and evaluation of supramolecular systems, assembled from its components by means of hydrogen bonding, using the self-complementary 2-pyridone motif. The thesis is divided in two parts. READ MORE

  3. 3. Synthesis and functionalization of ring-fused 2-pyridones Targeting pili formation in E. coli

    University dissertation from Umeå : Kemi

    Author : Nils Pemberton; Umeå universitet.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes;

    Abstract : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. READ MORE

  4. 4. Investigation of Kinetically Labile Supramolecu-lar System Addressing Substrate Selectivity in the Catalytic Epoxidations of Olefins

    University dissertation from Organic Chemistry, Lund University

    Author : Fabrice Odille; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; enantioselectivity; Salen Mn III ; substrate selectivity; porphyrin; Jacobsen-Katsuki epoxidation; supramolecular catalysis; Hydrogen-bond; 2-pyridone;

    Abstract : This thesis is devoted to the development and investigation of a supramolecular system used to catalyze Jacobsen-Katsuki epoxidations with the aim to attain substrate selectivity without product inhibition. The supramolecular catalyst is composed of two well-defined entities or units: a catalytic and a receptor. READ MORE

  5. 5. Peptidomimetics based on ring-fused 2-pyridones probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors

    University dissertation from Umeå : Kemi

    Author : Veronica Åberg; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; peptidomimetic; antibacterial; pili; Escherichia coli; virulence; amyloid; Alzheimer’s.; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. READ MORE