Search for dissertations about: "2D-DIGE"

Showing result 1 - 5 of 7 swedish dissertations containing the word 2D-DIGE.

  2. 1. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Author : Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  4. 2. Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia

    Author : Jenny Hadrévi; Albert Crenshaw; Fatima Pedrosa-Domellöf; Fredrik Hellström; Bijar Ghafouri; Mary F Barbe; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Trapezius myalgia; proteomics; 2D-DIGE; metabolomics; microdialysate; biopsies; anatomi; Human Anatomy;

    Abstract : Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. READ MORE

  5. 3. Proteomic Characterization of Induced Developmental Neurotoxicity

    Author : Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Abstract : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. READ MORE

  6. 4. Proteomics and metabolomics in biological and medical applications

    Author : Liudmila Shiryaeva; Wolfgang P. Schröder; Pernilla Wikström; Peter Roepstroff; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2D-DIGE; biomarkers; cold-acclimation; conifer; freezing tolerance; GC-MS; metabolomics; multiple hypothesis test; multivariate analysis; OPLS-DA; Picea obovata; plasma; prostate cancer; proteomics; ProteoMiner; Siberian spruce;

    Abstract : Biological processes in living organisms consist of a vast number of different molecular networks and interactions, which are complex and often hidden from our understanding. This work is focused on recovery of such details for two quite distant examples: acclimation to extreme freezing tolerance in Siberian spruce (Picea obovata) and detection of proteins associated with prostate cancer. READ MORE

  7. 5. Human Skeletal Muscle : a basic proteomic approach

    Author : Jenny Hadrevi; Fatima Pedrosa-Domellöf; Högskolan i Gävle; []
    Keywords : ;

    Abstract : The trapezius is a muscle of clinical interest due to its susceptibility to chronic work related musculoslteletal disorders. The mechanisms underlying these conditions are not fully understood. READ MORE