Search for dissertations about: "32P-postlabeling"

Found 4 swedish dissertations containing the word 32P-postlabeling.

  1. 1. High-performance liquid chromatography for analysis of 32P-Postlabeled DNA adducts

    Author : Magnus Zeisig; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; DNA adducts; 32P-postlabeling; HPLC; method development;

    Abstract : High-Performance Liquid Chromatography for Analysis of 32P-Postlabeled DNA Adducts Magnus Zeisig Center for Nutrition and Toxicology, Department of Bioscience at Novum, Karolinska Institutet, Novum, S-141 57 Huddinge, SwedenThe formation of DNA adducts, i.e. READ MORE

  2. 2. DNA adducts as biomarkers of exposure to some dietary carcinogens

    Author : Tina Jurén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Humans are exposed to many chemicals via intake of food and drink and there are strong associations between dietary factors and cancer. Exposure to the dietary carcinogens acrylamide and acetaldehyde are potential health risks that have made the headlines. High levels of acrylamide are found in various food items, such as potato chips. READ MORE

  3. 3. Biomarkers for DNA damage in human biomonitoring

    Author : Natalia Kotova; Dag Jenssen; Jan Grawé; Lilianne Abramsson-Zetterberg; Mats Ljungman; Stockholms universitet; []
    Keywords : biomonitoring; biomarkers; DNA damage; cancer; diet; UV-light; molekylärgenetik; Molecular Genetics;

    Abstract : Genomic DNA in humans is constantly exposed to different kinds of damage. Therefore, it is desirable to implement methods for detecting and measuring of inflicted body burden. Human biomonitoring (HBM) can here be a useful tool as a link between environmental exposure and disease outcome. READ MORE

  4. 4. Aldehyde toxicity in human oral epithelium

    Author : Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

    Abstract : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. READ MORE