Search for dissertations about: "5-HT3"

Showing result 1 - 5 of 16 swedish dissertations containing the word 5-HT3.

  2. 1. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism

    Author : Susanne Henningsson; Göteborgs universitet; []
    Keywords : serotonin; 5-HTTLPR; TPH2; 5-HT3; sex steroids; androgen receptor; estrogen receptor; genetics; gene-gene interaction; social phobia; anxiety; premenstrual dysphoric disorder; depression; personality; autism; transsexualism; amygdala; emotional perception; life events;

    Abstract : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. READ MORE

  4. 2. The serotonin receptor type 3 in chronic and experimental human muscle pain

    Author : Nikolaos Christidis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT3 receptor; Granisetron; Human muscles; Muscle biopsy; Pain; Pressure pain threshold; Visual Analogue Scale; Randomized Controlled Double-blind Trial;

    Abstract : The main aim of this thesis was to gain a better understanding of the influence of serotonin on chronic craniofacial muscle pain. The thesis comprised a basic science part and a human experimental part. READ MORE

  5. 3. Functional Models in the Search for Pharmacological Treatment of Urinary Incontinence : The Role of Adrenergic, Cholinergic, and Serotonergic Receptors

    Author : Ali-Reza Modiri; Karl-Erik Andersson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Stress incontinence and overactive bladder are disorders with a common symptom, urinary incontinence, which is a serious medical and social handicap. Several neurotransmitters regulate the function of the lower urinary tract, including noradrenaline, acetylcholine, and serotonin. READ MORE

  6. 4. Reactivity of human omental blood vessels. Effects of 5-hydroxytryptamine, substance P and the intravenous anaesthetic propofol

    Author : Susanna Wallerstedt; Anestesiologi och intensivvård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensivvård; intensive care; Anaesthesiology; endothelium; calcium; human; hyperpolarization; K channels; nitric oxide; omental artery; omental vein; propofol; receptors; Anestesiologi; serotonin; sympathetic nervous system; substance P;

    Abstract : Regulation of blood flow involves several endogenous substances and mechanisms, and exogenous substances may also affect the blood flow. In the present thesis, human omental blood vessels were investigated in vitro concerning (i) characteristics of 5-hydroxytryptamine (5-HT) receptors; (ii) mediators of substance P (SP)-induced relaxation; (iii) direct and indirect (via effects on sympathetic neurotransmission) effects of the intravenous anaesthetic propofol. READ MORE

  7. 5. Biomarkers in chronic and experimental human muscle pain

    Author : Sofia Louca Jounger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 5-HT;

    Abstract : The main aim of this thesis was to improve the knowledge ofthe peripheral mechanisms that may participate in the underlying pathophysiology of chronic temporomandibular disorders (TMD) myalgia i.e. pain that is experienced locally in the jaw muscles and has myofascial trigger points. READ MORE