Search for dissertations about: "7-azaindole"

Found 2 swedish dissertations containing the word 7-azaindole.

  2. 1. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors

    Author : Yongjin Xu; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RET kinase; kinase inhibitor; DFG-out; photoparmacology; azoheteroarene; Buchwald-Hartwig coupling; quinoline; 7-azaindole;

    Abstract : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. READ MORE

  4. 2. Studies of molecular systems with multiconfigurational methods

    Author : Jonna Stålring; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; excited state geometry optimizations; multiconfigurational methods; two-photon transition intensities; the C3H2 isomers; quantum chemistry; spectroscopy; Teoretisk kemi; Theoretical chemistry; kvantkemi; the ammonia dimer interaction energy;

    Abstract : Research in theoretical chemistry is aimed at finding computational algorithms that produce as accurate results as possible, for as large molecules as possible, with a minimum of computational effort and to apply these methods to molecular systems of chemical interest. The most accurate theoretical methods, often referred to as ab initio methods, are derived from the fundamental laws of physics and they do not rely on any empirical information. READ MORE