Search for dissertations about: "72 polymorphism"

Showing result 1 - 5 of 14 swedish dissertations containing the words 72 polymorphism.

  2. 1. Molecular Genetic Analysis in B-cell Lymphomas : A Focus on the p53 Pathway and p16INK4a

    Author : Norafiza Zainuddin; Gunilla Enblad; Richard Rosenquist; Mattias Berglund; Kirsten Gronbaek; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diffuse large B-cell lymphoma; chronic lymphocytic leukemia; TP53 mutation; MDM2 SNP309; codon 72 polymorphism; p16INK4a methylation; Clinical genetics; Klinisk genetik; Molecular biology; Molekylärbiologi; Haematology; Hematologi; Tumour biology; Tumörbiologi; Clinical Genetics; Klinisk genetik; Medical Genetics; Medicinsk genetik; Molekylär genetik; Molecular Genetics; Oncology; Onkologi; Pathology; Patologi;

    Abstract : The presence of TP53 mutations has been associated with inferior outcome in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In DLBCL, the impact of the TP53 codon 72 polymorphism and MDM2 SNP309 has not been clearly elucidated, whereas MDM2 SNP309 was suggested as a poor-prognostic marker in CLL. READ MORE

  4. 2. CYP2D6-polymorphism and effect of adjuvant tamoxifen in breast cancer patients

    Author : Linda Thorén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Adjuvant tamoxifen at the standard dose of 20 mg daily for five to ten years reduces the risk for relapse and mortality in hormone sensitive breast cancer. The effect however varies and no early marker of poor response is yet available. READ MORE

  5. 3. Autoantibodies as markers of beta-cell autoimmunity in children

    Author : Hanna Holmberg; Johnny Ludvigsson; Mona Landin-Olsson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Autoantibodies; Beta-cell autoimmunity; Children; Breast-feeding; HLA haplotypes; Insulin gene; Paediatric medicine; Pediatrisk medicin;

    Abstract : Type 1 diabetes (T1D) is a chronic disease caused by destruction of the insulin producing beta-cells in the pancreas. The incidence of T1D has increased rapidly, especially in the Western world and among young children. READ MORE

  6. 4. Cervical cancer in Zimbabwe : viral and host factors : studies on pathogenesis of cervical cancer in Zimbabwe with special reference to type-specific human paillomavirus (HPV) infection and human cytokine gene polymorphisms

    Author : Grazyna Alicja Stanczuk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical cancer; cytokine gene polymorphism; and ethnic differences; Zimbabwe.;

    Abstract : Invasive cervical cancer (ICC) is the commonest cancer affecting Zimbabwean women. The recognition of the central role of the human papilloma virus (HPV) in the aetiopathogenesis of cervical cancer has led to application of HPV testing in the cervical screening and to the development of HPV vaccines for primary prevention of ICC. READ MORE

  7. 5. The role of human papillomavirus in adenocarcinoma of the uterine cervix

    Author : Sonia Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervix; Adenocarcinoma; HPV; Prevalence; Age; PCR; DNA-sequencing; p53; HPV16 - E6 gene - polymorphism;

    Abstract : Background: Cervical carcinoma is the third most common malignant disease in women worldwide. The absolute frequency of adenocarcinoma of cervix uteri has increased during the last decade and accounts for about 15-20% of invasive cervical cancers. READ MORE