Search for dissertations about: "8-oxo-7"

Showing result 1 - 5 of 6 swedish dissertations containing the word 8-oxo-7.

  2. 1. Oxidative damage and the DNA glycosylase MutYH

    Author : Kristina Jansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative damage; 8-oxo-7; 8-dihydro-2′-deoxyguanosine; Base excision repair; DNA glycosylase; Mismatch repair; DNA damage checkpoint; 9-1-1 complex; Glutathione-S-transferases; Colon cancer.;

    Abstract : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. READ MORE

  4. 2. Gene-environment interactions for arsenic metabolism and metal-related oxidatively generated DNA damage

    Author : Karin Engström; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AS3MT; methylation; polymorphism; 8-oxodG;

    Abstract : Over 100 million people around the world are exposed to high concentrations of arsenic (As) in drinking water, associated with a number of adverse health effects such as skin, lung and bladder cancer, vascular diseases and diabetes. In humans, As is metabolized via alternating reduction and methylation reactions, from inorganic As (iAs) into monomethylated (MMA) and dimethylated As (DMA). READ MORE

  5. 3. Particularly harmful particles? A study of airborne particles with a focus on genotoxicity and oxidative stress

    Author : Hanna Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : particulate matter; particles; genotoxicity; oxidative stress; DNA damage; inflammation; subway; tire-road; wood;

    Abstract : Today it is well established that particulate matter (PM) cause a wide range of health effects. The underlying mechanisms likely include inflammation, oxidative stress and genotoxicity. There is however a lack of knowledge regarding how particles from different sources contribute to these effects. READ MORE

  6. 4. Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity

    Author : Siamak Haghdoost; Mats Harms-Ringdahl; Steffen Loft; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidative stress; 8-oxo-dG; 8-oh-dG; Radiosensitivity; Toxicology; Toxikologi;

    Abstract : Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. READ MORE

  7. 5. Modulating the activity of OGG1 using small molecules to target the oxidative DNA damage response in cancer and inflammation

    Author : Bishoy M F Hanna; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The production of reactive oxygen species (ROS) is increased in several pathological conditions including cancer and inflammation. Multiple lines of evidence suggest that ROS are involved in signaling events that promote tumorigenesis and inflammatory responses. READ MORE