Search for dissertations about: "8-oxodG"

Found 5 swedish dissertations containing the word 8-oxodG.

  2. 1. Gene-environment interactions for arsenic metabolism and metal-related oxidatively generated DNA damage

    Author : Karin Engström; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AS3MT; methylation; polymorphism; 8-oxodG;

    Abstract : Over 100 million people around the world are exposed to high concentrations of arsenic (As) in drinking water, associated with a number of adverse health effects such as skin, lung and bladder cancer, vascular diseases and diabetes. In humans, As is metabolized via alternating reduction and methylation reactions, from inorganic As (iAs) into monomethylated (MMA) and dimethylated As (DMA). READ MORE

  4. 2. Method development for analysis of 8-oxodG as a biomarker for oxidative stress

    Author : Tim Hofer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxidative damage to DNA gives oxidation of DNA bases and strand breaks that can cause mutations leading to cancer. Various forms of agents are capable of oxidising DNA in vivo including peroxides, singlet oxygen and UV- or gamma-irradiation. Oxidation of DNA bases occurs mainly at dG, giving stable DNA adducts such as 8-oxodG and FapydG. READ MORE

  5. 3. Oxidative damage and the DNA glycosylase MutYH

    Author : Kristina Jansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative damage; 8-oxo-7; 8-dihydro-2′-deoxyguanosine; Base excision repair; DNA glycosylase; Mismatch repair; DNA damage checkpoint; 9-1-1 complex; Glutathione-S-transferases; Colon cancer.;

    Abstract : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. READ MORE

  6. 4. Protection of Biomolecules by Antioxidants - Mechanisms and Applications

    Author : Carl Grey; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; dG; antioxidants; mass spectrometry; Analytical chemistry; Analytisk kemi; Food and drink technology; Livsmedelsteknik; Bioteknik; Biotechnology; DNA; Oxidation; Protein; Fenton reaction;

    Abstract : Reactive oxygen species (ROS) consisting of various oxygen-based free radicals as well as other reactive non-radical species produced in O2-related metabolism or through other processes are involved in the oxidation of such vital biomolecules as DNA, proteins and lipids. The types of oxidation represented here are known to cause many different diseases and disorders in human beings, such as cancer, Alzheimer's disease and ageing. READ MORE

  7. 5. Particularly harmful particles? A study of airborne particles with a focus on genotoxicity and oxidative stress

    Author : Hanna Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : particulate matter; particles; genotoxicity; oxidative stress; DNA damage; inflammation; subway; tire-road; wood;

    Abstract : Today it is well established that particulate matter (PM) cause a wide range of health effects. The underlying mechanisms likely include inflammation, oxidative stress and genotoxicity. There is however a lack of knowledge regarding how particles from different sources contribute to these effects. READ MORE