Search for dissertations about: "96-well technology"

Showing result 1 - 5 of 6 swedish dissertations containing the words 96-well technology.

  1. 1. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels

    University dissertation from Biotechnology, Lund University

    Author : Amro Hanora; Lunds universitet.; Lund University.; [2005]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; macroporous; Biologically active compounds; Biotechnology; Läkemedelsteknik och relaterad teknik; Pharmaceutical and related technologies; Polymerteknik; biopolymers; Biokemisk teknik; Polymer technology; Makromolekylär kemi; Biochemical technology; Affinity chromatography; Ion exchange chromatography; Expanded bed adsorption chromatography.; Macromolecular chemistry; High through put screening; lactica acids; Endotoxin; Plasmid DNA; Cryogel columns; Bioteknik;

    Abstract : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. READ MORE

  2. 2. Experimental Designs at the Crossroads of Drug Discovery

    University dissertation from Umeå : Kemi

    Author : Ing-Marie Olsson; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. READ MORE

  3. 3. Thermostable glycosidases and glycosynthases as biocatalysts in green chemistry applications

    University dissertation from Umeå : Kemi

    Author : Tania Pozzo; Lunds universitet.; Lund University.; [2012]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Green chemistry; 3D sturcture; Glycosyl hydrolases; Glycosynthases; Alkyl glucosides; Oligosaccharides; Flavonoids;

    Abstract : Popular Abstract in Swedish Idag baserat på konceptet grön kemi - börjar man att utveckla nya miljövänliga processer i produktionen av kemikalier, genom att använda förnyelsebara råvaror och minska giftigt avfall. I denna avhandling används enzymer för att bilda kemikalier som en del i utvecklingen av nya miljöprocesser. READ MORE

  4. 4. Approaches to Optimizing High Content Confocal Microscopy

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Erland Lewin; KTH.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis presents two methods for improving high contentconfocal microscopy.The author's part in the first, "Toward a confocal subcellular atlasof the human proteome" was automating image capture of foursimultaneously tagged structures in cells in 96 well plates. In total,thousands of images of hundreds of proteins in cells. READ MORE

  5. 5. High-throughput protein analysis using mass spectrometry-based methods

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Tove Boström; KTH.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteomics; mass spectrometry; affinity proteomics; immunoenrichment; immunoprecipitation; IMAC; screening; protein production; protein purification; ISET; quantification; SILAC; stable isotope standard; antibody validation; Biotechnology; Bioteknologi;

    Abstract : In the field of proteomics, proteins are analyzed and quantified in high numbers. Protein analysis is of great importance and can for example generate information regarding protein function and involvement in disease. Different strategies for protein analysis and quan- tification have emerged, suitable for different applications. READ MORE