Search for dissertations about: "Aβ oligomers"

Showing result 1 - 5 of 13 swedish dissertations containing the words Aβ oligomers.

  1. 1. Pathogenic Mechanisms of the Arctic Alzheimer Mutation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Charlotte Sahlin; Uppsala universitet.; [2007]
    Keywords : Neurosciences; Alzheimer s disease; Arctic mutation; Amyloid precursor protein; Amyloid-β; APP processing; Aβ oligomers; Docosahexaenoic acid; Neurovetenskap;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. READ MORE

  2. 2. Targeting cytotoxic species in amyloid diseases

    University dissertation from Umeå : Umeå universitet

    Author : Malin Lindhagen Persson; Umeå universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. READ MORE

  3. 3. Role of pro-inflammatory S100A9 protein in amyloid-neuroinflammatory cascade in Alzheimer’s disease and traumatic brain injury

    University dissertation from Umeå : Umeå University

    Author : Chao Wang; Umeå universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S100A9; ; Alzheimer s disease; Traumatic brain injury; Amyloid; Neuroinflammatory; medicinsk biokemi; Medical Biochemistry;

    Abstract : Background Traumatic brain injury (TBI) is a complex disease with a spectrum of symptoms and disabilities. Over the past decade TBI has become the focus of research due to growing epidemiological and clinical evidences that TBI incidences are strong risk factors for Alzheimer’s disease (AD). READ MORE

  4. 4. Therapeutic and functional studies in animal models of Alzheimer's disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Astrid Gumucio; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neuroscience; Neurovetenskap; Medical Cell Biology; Medicinsk cellbiologi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. READ MORE

  5. 5. The influence of lysozyme and oligothiophenes on amyloid-β toxicity in models of Alzheimer’s disease

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Linnea Sandin; Linköpings universitet.; Linköpings universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia worldwide. Apart from dominantly inherited mutations, age is the major risk factor and as life expectancy increases the prevalence for AD escalates dramatically. READ MORE