Search for dissertations about: "Aβ oligomers"

Showing result 1 - 5 of 21 swedish dissertations containing the words Aβ oligomers.

2. 1. Structure and dynamics of amyloid-beta oligomers

   Author : Faraz Vosough; Andreas Barth; Henrietta Nielsen; Oxana Klementieva; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta peptide; Aβ oligomer; infrared spectroscopy; FTIR; protein aggregation; β-sheet; interaction; lithium; nickel; biokemi; Biochemistry;

   Abstract : Alzheimer's disease (AD) is the most common cause of dementia, affects tens of millions of people all over the world and inflicts huge socioeconomic costs on the societies. AD is a neurodegenerative disease; it progresses over time and is highly debilitating at the advanced stages. READ MORE

4. 2. Pathogenic Mechanisms of the Arctic Alzheimer Mutation

   Author : Charlotte Sahlin; Lars Lannfelt; Lars Nilsson; Christian Haass; Uppsala universitet; []
   Keywords : Neurosciences; Alzheimer s disease; Arctic mutation; Amyloid precursor protein; Amyloid-β; APP processing; Aβ oligomers; Docosahexaenoic acid; Neurovetenskap;

   Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. READ MORE

5. 3. Targeting cytotoxic species in amyloid diseases

   Author : Malin Lindhagen Persson; Anders Olofsson; Lars Tjernberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

   Abstract : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. READ MORE

6. 4. Role of pro-inflammatory S100A9 protein in amyloid-neuroinflammatory cascade in Alzheimer’s disease and traumatic brain injury

   Author : Chao Wang; Ludmilla Morozova-Roche; Jonathan Gilthorpe; Øyvind Halskau; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S100A9; Aβ; Alzheimer s disease; Traumatic brain injury; Amyloid; Neuroinflammatory; medicinsk biokemi; Medical Biochemistry;

   Abstract : Background Traumatic brain injury (TBI) is a complex disease with a spectrum of symptoms and disabilities. Over the past decade TBI has become the focus of research due to growing epidemiological and clinical evidences that TBI incidences are strong risk factors for Alzheimer’s disease (AD). READ MORE

7. 5. Alzheimer disease : subcellular Aβ mechanisms and treatment strategies

   Author : Yang Gao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular level and explore effective AD treatment strategies. READ MORE