Search for dissertations about: "A Karlen"
Showing result 1 - 5 of 28 swedish dissertations containing the words A Karlen.
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1. Towards the Development of Photoswitchable β-Hairpin Mimetics
Abstract : Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. READ MORE
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2. Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins
Abstract : In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. READ MORE
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3. Ulcerative colitis and cancer with special reference to the increased colorectal cancer risk
Abstract : The association between ulcerative colitis (UC) and cancer in a defined geographical region in Sweden was analyzed. UC patients have an increased overall risk of cancer of 40%, mainly due not only to the well-known increased risk of colorectal cancer (CRC) but also to the risk of hepatobiliary cancer associated with primary sclerosing cholangitis (PSC). READ MORE
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4. Probabilistic modeling of fatigue failures
Abstract : Fatigue is a well known failure mode in engineering that can have catastrophic consequences, such as loss of human life. Thus design against fatigue failure is very important. There are many sources of scatter present in fatigue, for instance; the difference in load in-between users of a product, material scatter and scatter in the production. READ MORE
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5. A multivariate approach to characterization of drug-like molecules, proteins and the interactions between them
Abstract : En sjukdom kan många gånger härledas till en kaskadereaktion mellan proteiner, co-faktorer och substrat. Denna kaskadreaktion blir många gånger målet för att behandla sjukdomen med läkemedel. För att designa nya läkemedelsmoleyler används vanligen datorbaserade verktyg. READ MORE