Search for dissertations about: "A Lof"

Showing result 6 - 10 of 10 swedish dissertations containing the words A Lof.

  2. 6. Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy

    Author : Qing Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic leukemia (CLL). However, a sub-group of patients develops resistance to ibrutinib therapy. READ MORE

  4. 7. Targeting allelic loss in colorectal cancer

    Author : Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Abstract : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. READ MORE

  5. 8. Laser welding and cladding : the effects of defects on fatigue behaviour

    Author : Md. Minhaj Alam; Stewart Williams; Luleå tekniska universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Manufacturing Systems Engineering; Produktionsutveckling;

    Abstract : The thesis focuses on weld defects in laser processed materials (for laser welding, laser hybrid arc welding and laser cladding) and their effect on the fatigue life of components. Component properties were studied with particular emphasis on the macro and micro surface geometry, weld defects and clad defects. READ MORE

  6. 9. Defects in E-PBF Ti-6Al-4V and their Effect on Fatigue Behaviour : Characteristics, Distribution and Impact on Life

    Author : Viktor Sandell; Marta-Lena Antti; Pia Åkerfeldt; Thomas Hansson; Hans Andersson; Luleå tekniska universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Defects; Additive Manufacturing; Ti-6Al-4V; Probabilistic Modelling; Fatigue; Materialteknik; Engineering Materials;

    Abstract : Layer by layer manufacturing (additive manufacturing, AM) of metals is emerging as an alternative to conventional subtractive manufacturing with the goal of enabling near net-shape production of complex part geometries with reduced material waste and shorter lead times. Recently this field has experienced rapid growth through industrial adaptation but has simultaneously encountered challenges. READ MORE

  7. 10. Human Behaviour Recognition of Elderly in Single-Resident IoT Enabled Smart Homes: An Applied Machine Learning Approach

    Author : Zahraa Shahid; Saguna Saguna; Christer Åhlund; Flora Salim; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pervasive Mobile Computing; Distribuerade datorsystem;

    Abstract : In Human Activity Recognition (HAR) systems, activities of daily living/human behaviour are recognized using sensor data by applying data mining techniques and machine learning algorithms to the collected data. This allows for customised and automated services to support humans’ daily living. READ MORE