Search for dissertations about: "A. Lambert"
Showing result 1 - 5 of 22 swedish dissertations containing the words A. Lambert.
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1. Mutant p53 reactivation by prima-1 : molecular mechanism and biological effects
Abstract : Cancer has become one of the leading causes of death worldwide. It is now clear that tumors arise due to the malfunction of a number of genes, thus emphasising the importance of targeted therapies directed to crucial types of genetic alterations. READ MORE
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2. Fluctuations of smooth linear statistics of determinantal point processes
Abstract : We study eigenvalues of unitary invariant random matrices and other de-terminantal point processes. Paper A investigates some generalizations ofthe Gaussian Unitary Ensemble which are motivated by the physics of freefermions. READ MORE
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3. Exploring small heat shock protein chaperones by crosslinking mass spectrometry
Abstract : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. READ MORE
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4. Immune evasion and dissemination of Toxoplasma gondii
Abstract : Toxoplasma gondii is an obligate intracellular protozoan parasite which propagates in a complex life cycle where infection of Felidae family-members (Cats) results in sexual recombination whereas all other warm-blooded animals are intermediate hosts. Approximately one third of the human population is estimated to be chronically infected by this parasite. READ MORE
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5. How to model temporal changes in epidemiological data : Treatment trajectories in men with prostate cancer
Abstract : Owing to the improvements in detection, diagnostics, and treatment, many men currently diagnosed with prostate cancer (PCa) have a low risk of PCa death. For many men PCa has become a chronic disease with a small risk of progression that remains even decades after date of diag-nosis. READ MORE