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Showing result 1 - 5 of 12 swedish dissertations matching the above criteria.

2. 1. Evaluation of neurotoxic properties of gliotoxin

   Author : Viktoria Axelsson; Anna Forsby; Marion Ehrich; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycotoxin; gliotoxin; A. fumigatus; cytotoxicity; neurotoxicity; Neurochemistry; Neurokemi;

   Abstract : The occurrence of mould in food and animal feed is a severe problem due to the secondary metabolites, called mycotoxins, which can possess toxic activity. Aspergillus fumigatus is a common fungus found in improperly stored animal feed and the abundance of spores of the fungus is frequently spread into the air. READ MORE

4. 2. Analysis of Secondary Metabolites from Aspergillus fumigatus and Penicillium nalgiovense : Antimicrobial Compounds from Filamentous Fungi Isolated from Extreme Environments

   Author : Stefan Svahn; Lars Bohlin; Björn Olsen; Ulf Göransson; Erja Chryssanthou; Douglas Kinghorn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aspergillus fumigatus; Penicillium nalgiovense; secondary metabolites; invasive aspergillosis; elicitation; gliotoxin; bis methyl gliotoxin; amphotericin B; Pharmacognosy; Farmakognosi;

   Abstract : This thesis describes the cultivation and extraction of filamentous fungi isolated from extreme environments in the search for new antibiotic compounds. Filamentous fungi are a rich source of medicines including antibiotics, and it is believed that many currently unknown fungal species and bioactive fungal metabolites remain to be discovered. READ MORE

5. 3. Fungal colonization and infection in cystic fibrosis : prevalence, consequences and intervention

   Author : Mahasin Al Shakirchi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Cystic fibrosis (CF) is an inherited progressive disease affecting multiple organs. The main cause of death in CF is related to the respiratory complications. Inflammation and infection, triggered by colonizing microorganisms in CF airways, cause structural lung damage resulting in respiratory failure and death. READ MORE

6. 4. Discovery of Novel Fatty Acid Dioxygenases and Cytochromes P450 : Mechanisms of Oxylipin Biosynthesis in Pathogenic Fungi

   Author : Inga Hoffmann; Ernst H Oliw; Alan R Brash; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Fusion protein; Linoleate diol synthase; Allene oxide synthase; Cyclooxygenase; Oxygenase; HPLC; Mass spectrometry; Hydroperoxide isomerase; Aspergillus; Fusarium oxysporum; Pharmaceutical Biochemistry; Farmaceutisk biokemi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Dioxygenase-cytochrome P450 (DOX-CYP) fusion enzymes are present in diverse human and plant pathogenic fungi. They oxygenate fatty acids to lipid mediators which have regula­tory functions in fungal development and toxin production. READ MORE

7. 5. Catalytic and Structural Properties of Heme-containing Fatty Acid Dioxygenases : Similarities of Fungal Dioxygenases and Cyclooxygenases

   Author : Ulrike Garscha; Ernst Oliw; Per-Johan Jakobsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dioxygenase; prostaglandin H synthase; Gaeumannomyces graminis; Aspergilli; hydroperoxide isomerase; linoleate diol synthase; cytochrome P450; oxylipin; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Abstract : 7,8-Linoleate diol synthase (7,8-LDS) of the take-all pathogen of wheat, Gaeumannomyces graminis, converts linoleic acid to 8R-hydroperoxyoctadecadienoic acid (8-HPODE) by 8-dioxygenase activity (8-DOX), and further isomerizes the hydroperoxide to 7S,8S-dihydroxyoctadecadienoic acid (7,8-DiHODE) by hydroperoxide isomerase activity. Sequence alignment showed homology to prostaglandin H synthase (PGHS), and both enzymes share structural and catalytic properties. READ MORE