Search for dissertations about: "A2A receptors"
Showing result 6 - 10 of 26 swedish dissertations containing the words A2A receptors.
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6. Physiological roles of A1 and A2A adenosine receptors : studies using genetically modified mice
Abstract : Since adenosine receptors were identified and cloned, their roles in animals and humans have been extensively studied. Because pharmacological tools have limitations, we have used mice in which adenosine receptors have been deleted to further study their roles under physiological and pathophysiological conditions. READ MORE
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7. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function
Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE
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8. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Abstract : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. READ MORE
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9. Adenosine receptors and stress : studies using methylmercury, caffeine and hypoxia
Abstract : Brain development is a precisely organized process that can be disturbed by various stress factors present in the diet (e.g. exposure to xenobiotics) as well as insults such as decreased oxygen supply. READ MORE
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10. Effects of adenosine and acetylcholine on the lacrimal gland
Abstract : A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. READ MORE