Search for dissertations about: "ABL"

Showing result 1 - 5 of 45 swedish dissertations containing the word ABL.

  2. 1. Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes

    Author : Thoas Fioretos; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CRKL; CRK; ABL; BCR; acute lymphoid leukemia; chronic myeloid leukemia; Philadelphia chromosome; Molecular Genetics; Cytogenetics; IFN-alfa; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positive acute lymphoid leukemia (ALL). READ MORE

  4. 2. c-Abl, a putative regulator of b-cell death

    Author : Robert Hägerkvist; Uppsala universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  5. 3. Molecular Monitoring of Chronic Myeloid Leukemia Treated with Imatinib Mesylate

    Author : Yuan Wei; Göteborgs universitet; []
    Keywords : CML; imatinib; BCR-ABL; apoptosis; mutation; T-lymphocyte;

    Abstract : The BCR-ABL fusion gene product is a constitutively activated tyrosine kinase, which is fundamental in the pathogenesis of chronic myeloid leukemia (CML). Imatinib mesylate (imatinib, Glivec® or Gleevec®), a small molecule inhibitor of the BCR-ABL tyrosine kinase, is now the first-line treatment for all newly diagnosed chronic phase CML patients. READ MORE

  6. 4. Molecular and functional studies of the BCR/ABL1 fusion gene

    Author : Petra Johnels; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; onkologi; Cytologi; cancerology; oncology; Cytology; gene expression profiling; acute lymphoblastic leukemia; chronic myeloid leukemia; Ph chromosome; BCR ABL; extracellulära vätskor; Clinical genetics; Klinisk genetik; cancer;

    Abstract : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. READ MORE

  7. 5. Studies of leukotriene C4 synthase expression and regulation in chronic myeloid leukaemia

    Author : Cecilia Roos; Susanne Tornhamre; Anita Sjölander; Karlstads universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; leukotriene C4 synthase; chronic myeloid leukaemia; p210 BCR-ABL; myelopoiesis; imatinib mesylate; Cell biology; Cellbiologi; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Leukotriene (LT) C4 is generated through conjugation of LTA4 with glutathione by the actions of leukotriene C4 synthase (LTC4S). This biologically potent mediator of asthma and inflammation has also been suggested to play a regulatory role in human myelopoiesis and is overproduced by blood and bone marrow cells from patients with chronic myeloid leukaemia (CML). READ MORE