Search for dissertations about: "ADAM10"

Showing result 1 - 5 of 8 swedish dissertations containing the word ADAM10.

  2. 1. α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Olav Andersen; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP2; ADAM10; TACE; Alzheimer s Disease; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The amyloid-β precursor protein (APP) has been widely studied due to its role in Alzheimer´s disease (AD). When APP is sequentially cleaved by β- and γ-secretase, amyloid-β (Aβ) is formed. Aβ is prone to aggregate and is toxic to neurons. READ MORE

  4. 2. The amyloid-β precursor protein (APP)-binding protein Fe65 and APP processing

    Author : Niina Koistinen; Anna-Lena Ström; Stefan Kins; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; APP; Fe65; ADAM10; Alzheimer s disease; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of neurotoxic amyloid-β (Aβ) peptide. Aβ is generated by sequential cleavage of the amyloid-β precursor protein (APP) by β- and then γ-secretase. READ MORE

  5. 3. Processing of the APP family by the α-secretases ADAM10 and TACE

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Lars Nilsson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. READ MORE

  6. 4. Losing connections in Alzheimer disease : the amyloid precursor protein processing machinery at the synapse

    Author : Jolanta L Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synaptic degeneration is one of the earliest characteristics of Alzheimer disease (AD). The amyloid β-peptide (Aβ) plays a critical role in the pathology of AD and therefore thorough understanding of its production and functions is of outmost importance. READ MORE

  7. 5. Models of the lung tissue microenvironment for studies of human myeloid cell function

    Author : Puran Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Studies of the immune system requires knowledge concerning not only the perturbating event itself, i.e. specific microorganisms, and how it interacts with immune cells but also how it functions in its natural environment – tissues. READ MORE