Search for dissertations about: "ADAR"

Showing result 1 - 5 of 16 swedish dissertations containing the word ADAR.

  2. 1. The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

    Author : Victor Karlström; Neus Visa; Ayelet Lamm; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; Alternative splicing; miRNA processing; neuronal differentiaton; molekylär biovetenskap; Molecular Bioscience;

    Abstract : The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals. READ MORE

  4. 2. Regulation and Function of RNA Editing in the Mammalian Brain

    Author : Chammiran Daniel; Marie Öhman; Joshua Rosenthal; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; GABAA receptor; Gabra-3; Molecular Biology; molekylärbiologi;

    Abstract : Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in eukaryotes that increases the protein diversity. Adenosine deaminases acting on RNA (ADARs) are the enzymes that catalyze this conversion. READ MORE

  5. 3. Regulation of site-selective A-to-I RNA editing : During mammalian brain development

    Author : Helene Wahlstedt; Marie Öhman; Mary O'connell; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editering; ADAR; brain development; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in mammals that contributes to increase the protein diversity. Adenosine deaminases that act on RNA (ADARs) are the enzymes catalyzing RNA editing. ADARs are particularly active within the brain where they act on transcripts involved in neurotransmission. READ MORE

  6. 4. Regulation of RNA Editing : The impact of inosine on the neuronal transcriptome

    Author : Mikaela Behm; Marie Öhman; André Gerber; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; miRNA; Neuron; Brain development; Synapse; Molecular Biology; molekylärbiologi;

    Abstract : The transcriptome of the mammalian brain is extensively modified by adenosine to inosine (A-to-I) nucleotide conversion by two adenosine deaminases (ADAR1 and ADAR2). As adenosine and inosine have different base pairing properties, A-to-I RNA editing shapes the functional output of both coding and non-coding RNAs (ncRNAs) in the brain. READ MORE

  7. 5. Diversifying the transcriptome : Adenosine-to-inosine RNA editing in the mammalian brain

    Author : Albin Widmark; Neus Visa; Joshua Rosenthal; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; microRNA; brain development; neuron; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Metazoan transcriptomes are extensively modified by adenosine-to-inosine (A-to-I) RNA editing, a process by which adenosines within double-stranded RNA are enzymatically deaminated to form inosines. Inosines has base-pairing characteristics similar to guanosine, meaning that A-to-I RNA editing results in functional rewriting of transcripts, affecting many biological processes. READ MORE