Search for dissertations about: "ADP-ribosylation"

Showing result 1 - 5 of 18 swedish dissertations containing the word ADP-ribosylation.

  1. 1. Regulation of TGFβ signaling by long non-coding RNAs and ADP-ribosylation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Panagiotis Papoutsoglou; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; signal transduction; long non-coding RNAs; ADP-ribosylation; transcriptional regulation; chromatin remodeling; Medicinsk vetenskap; Medical Science;

    Abstract : Transforming growth factor β (TGFβ) signaling pathways participate in embryonic development and tissue homeostasis and have a dual role in cancer. TGFβ acts as a tumor suppressor that promotes cell cycle arrest and apoptosis at initial stages of tumorigenesis. READ MORE

  2. 2. Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S

    University dissertation from Umeå universitet

    Author : Maria Henriksson; Umeå universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Pseudomonas aeruginosa; ADP-ribosylation; GAP; Ras superfamily; NAD; ExoS; 14-3-3; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. It uses a type III secretion dependent mechanism to translocate toxic effector proteins directly into the eukaryotic cell. READ MORE

  3. 3. Regulation of TGF-β Signaling by Post-Translational Modifications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Peter Lönn; Uppsala universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. READ MORE

  4. 4. Exoenzyme S of Pseudomonas aeruginosa cellular targets and interaction with 14-3-3

    University dissertation from Umeå : Medicinsk biovetenskap

    Author : Lubna Yasmin; Umeå universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExoS; ADP-ribosylation; 14-3-3 protein; Pseudomonas aeruginosa; Small GTPases; RAS; RAP; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that is a serious problem for immuno-compromised patients. Toxins such as exoenzyme (Exo) S, ExoT, ExoY and ExoU are secreted and translocated from the bacteria into the eukaryotic cell via the bacterial encoded type III secretion system. READ MORE

  5. 5. Lipid storage and secretion. Studies on VLDL assembly and foam cell formation

    University dissertation from Umeå : Medicinsk biovetenskap

    Author : Björn Magnusson; Göteborgs universitet.; Gothenburg University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADP-ribosylation factor 1; very low density lipoprotein; lipid droplet; adipocyte differentiation-related protein; hypoxia; foam cell;

    Abstract : This thesis deals with formation of two factors of upmost importance for the development of atherosclerosis: the triglyceride rich very low density lipoproteins 1 (VLDL1) and the lipid loaded macrophages ("foam cells"- characteristic features of the atherosclerotic lesion). Both these processes depend on the cellular accumulation of lipids. READ MORE