Search for dissertations about: "AICAR"

Showing result 1 - 5 of 10 swedish dissertations containing the word AICAR.

  2. 1. Glucotoxicity in Insulin-Producing β-Cells

    Author : Hanna K Nyblom; Peter Bergsten; Michael Welsh; Miriam Cnop; Uppsala universitet; []
    Keywords : Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

    Abstract : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. READ MORE

  4. 2. Nutrient and energy sensing in skeletal muscle

    Author : Atul S Deshmukh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; AMPK; mTOR; glucose metabolism; exercise; Akt; TBC1D1 D4; CaMK; NO-cGMP;

    Abstract : Nutrient overload and physical inactivity often leads to the development of obesity and type 2 diabetes. Acute over-nutrition can induce insulin resistance, while physical exercise enhances skeletal muscle insulin sensitivity. Like every living cell, skeletal muscle senses nutrient and energy signals and to adjust metabolic flux. READ MORE

  5. 3. Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes

    Author : Xiao Mei Song; Karolinska Institutet; Karolinska Institutet; []
    Keywords : exercise; fiber-type; glucose transport; hyperglycemia; obesity; signal transduction; skeletal muscle; NIDDM;

    Abstract : This dissertation work is focused on the insulin-signal-transduction pathways to glucose transport in skeletal muscle from animal models of NIDDM. The overall objective is to determine the effectiveness of different pharmacological treatments to improve insulin action in skeletal muscle. READ MORE

  6. 4. Novel pharmaceutical approaches to regulate glucose homeostasis

    Author : Maj Sundbom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Western sedentary life-style and calorie excess is causing an increased incidence of obesity and type 2 diabetes. When untreated, these diseases are associated with heart- and vascular disease, stroke, cancer, neuropathic pain, renal failure and infertility. READ MORE

  7. 5. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming

    Author : Stephan Glund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AMP-activated protein kinase; interleukin-6; exercise; glucose metabolism; lipid metabolism; adaptation to exercise.;

    Abstract : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. READ MORE