Search for dissertations about: "AICAR"

Showing result 6 - 10 of 10 swedish dissertations containing the word AICAR.

  2. 6. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

    Author : Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

    Abstract : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. READ MORE

  4. 7. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin

    Author : Yun Chau Long; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; metabolism; glucose; lipid; gene expression; AMP-activated protein kinase; calcineurin; exercise;

    Abstract : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. READ MORE

  5. 8. Insulin signalling and TBC1D1 in skeletal muscle metabolism

    Author : Ferenc Szekeres; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 2 diabetes mellitus (T2DM) has taken the form of a pandemic disease globally as people adopt a more western lifestyle. High circulating glucose levels indicates that an individual is in the risk zone for developing T2DM. One of the hallmarks for T2DM is insulin resistance in skeletal muscle. READ MORE

  6. 9. Transcriptional, epigenetic and lipidomic responses to metabolic interventions : implications for human obesity

    Author : Carolina Nylén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity is increasing worldwide in an epidemic manner and better prevention and treatments are urgently needed. Obesity is strongly associated with insulin resistance and predisposes for type 2 diabetes. READ MORE

  7. 10. Cell signaling and regulation of smooth muscle contraction from a physiological and a pathophysiological perspective

    Author : Lena Boberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis was to examine the cell signaling and regulation of smooth muscle in different smooth muscle tissues and under pathophysiological conditions. The thesis is based on 4 papers and the experimental work is based on in vitro studies in mouse. READ MORE