Search for dissertations about: "AIDS vaccines"

Showing result 1 - 5 of 21 swedish dissertations containing the words AIDS vaccines.

  2. 1. Alphavirus vectors as recombinant vaccines

    Author : Peter Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; Alphavirus; Synthetic vaccmes; Influenza A virus; HIV-I; SIV; DNA vaccines; AIDS vaccines; Influenza vaccine;

    Abstract : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. READ MORE

  4. 2. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

    Author : Britt Losman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

    Abstract : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. READ MORE

  5. 3. Improving the immunogenicity of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nearly 30 years have passed since the start of the global HIV epidemic and we are still unable to control the spread of the virus. HIV predominately infects cells crucial for the function of the immune system, integrates into the host genome and demonstrates a huge genetic variability, and the use of therapeutic antiretroviral drugs can restrain but not clear the infection. READ MORE

  6. 4. Strategies to enhance the potency of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite 30 years of intense research on HIV/AIDS, we have yet to arrive at a prophylactic vaccine that confers complete protection. This mission is complicated by the virus’s vast genetic variability and its ability to mask the targets for neutralizing antibodies. READ MORE

  7. 5. Roles in innate immune receptors : host – pathogen interactions and strengthening vaccines

    Author : Sanna Nyström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During the past decades our knowledge of innate immunology has increased drastically. This has improved our understanding about how innate immune cells can distinguish self from non-self, commensal bacteria from pathogens, and how it affects later adaptive immune responses. READ MORE