Search for dissertations about: "ALS"

Showing result 16 - 20 of 162 swedish dissertations containing the word ALS.

  2. 16. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Author : Hanna Wootz; Dan Lindholm; Håkan Aldskogius; Christopher Fowler; Uppsala universitet; []
    Keywords : Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE

  4. 17. Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis

    Author : Per Zetterström; Stefan L Marklund; Lawrence J. Hayward; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; protein misfolding; SOD1 conformation; disulfide-reduced; transgenic mice; cerebrospinal fluid; protein-protein interaction; antibodies; Clinical chemistry; Klinisk kemi; Clinical Chemistry; klinisk kemi;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is always fatal, usually through respiratory failure when the disease reaches muscles needed for breathing. Most cases are sporadic, but approximately 5–10% are familial. READ MORE

  5. 18. Superoxide dismutase 1 and amyotrophic lateral sclerosis

    Author : P. Andreas Jonsson; Stefan L. Marklund; David R. Borchelt; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; aggregates; ALS; amyotrophic lateral sclerosis; cerebrospinal fluid; disulfide-reduced; inclusions; misfolded; protective factor; SOD1; transgenic; Neurovetenskap; Neurology; Neurologi; Clinical Chemistry; klinisk kemi;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the spinal cord, brain stem and motor cortex, leading to paralysis, respiratory failure and death. In about 5% of ALS cases, the disease is associated with mutations in the CuZn-superoxide dismutase (hSOD1) gene. READ MORE

  6. 19. Misfolded superoxide dismutase-1 in sporadic and familial Amyotrophic Lateral Sclerosis

    Author : Karin Forsberg; Thomas Brännström; Irina Alafuzoff; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD-1 motor neuron; protein misfolding; intranuclear; antibodies; CNS; brain; patologi; Pathology;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative syndrome of unknown etiology that most commonly affects people in middle and high age. The hallmark of ALS is a progressive and simultaneous loss of upper and lower motor neurons in the central nervous system that leads to a progressive muscle atrophy, paralysis and death usually by respiratory failure. READ MORE

  7. 20. Of mice and men : SOD1 associated human amyotrophic lateral sclerosis and transgenic mouse models

    Author : Karin Sixtensdotter Graffmo; Thomas Brännström; Stefan Marklund; Elisabeth Englund; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aggregates; ALS; amyotrophic lateral sclerosis; inclusions; misfolded; vacuolisation; SOD1; transgenic; Pathology; Patologi;

    Abstract : Amyotrophic lateral sclerosis, ALS, is a progressive fatal neurodegenerative disorder affecting motor neurones in motor cortex, brain stem and spinal cord. This inevitably leads to paralysis, respiratory failure and death. READ MORE