Search for dissertations about: "AML1"

Showing result 1 - 5 of 6 swedish dissertations containing the word AML1.

  1. 1. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

    Author : Hebin Liu; Sven Påhlman; [2005]
    Keywords : RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

    Abstract : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. READ MORE

  2. 2. Characterisation of the leukaemia-associated ETO homologues

    University dissertation from Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University

    Author : Sofia Rondin Lindberg; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; SIN3B; corepressor; MTGR1; MTG16; ETO; AML1-ETO; AML; haematopoiesis; leukaemia; Hematologi; extracellulära vätskor;

    Abstract : Acute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in patients with AML. READ MORE

  3. 3. The role of the leukemia-associated ETO homologue repressors in hematopoiesis

    University dissertation from Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University

    Author : André Olsson; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MTGR1; ETO; MTG16; AML1-ETO; hematopoiesis; leukemia; diffferentiation; extracellular fluids; Haematology; Medicin människa och djur ; extracellulära vätskor; Hematologi; Medicine human and vertebrates ;

    Abstract : The fusion protein AML1-ETO is observed in acute myeloid patients with the chromosomal translocation t(8;21). Cells with this chimeric protein have impaired granulocytic and erythroid differentiation with accumulation of myeloblasts. The transcriptional co-repressor ETO (Eight Twenty One) was identified from the cloning of AML1-ETO. READ MORE

  4. 4. Characterisation of chromosomal aberrations in childhood leukaemia

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Author : Ann Nordgren; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chromosome aberrations; SKY; interphase-FISH; Childhood ALL;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. READ MORE

  5. 5. Studies on Molecular Genetics of B cell Development

    University dissertation from Panagiotis Tsapogas, Section for Immunology, BMC I-13, S-221 84, Lund

    Author : Panagiotis Tsapogas; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin; gene expression; B cell; EBF; class switching; TGF-beta; Immunology; transplantation; serologi; Immunologi; serology;

    Abstract : The development of immature progenitor cells into highly differentiated effector cells is a process central in modern medicine with applications in the fields of cell therapy as well as oncology. This thesis is focused on the molecular mechanisms that control the development of B lymphocytes. READ MORE