Search for dissertations about: "AMP"

Showing result 21 - 25 of 151 swedish dissertations containing the word AMP.

2. 21. Regulation of steroidogenesis : cAMP-dependent transcription in adrenocortical cells

   Author : Marit Bakke; Karolinska Institutet; Karolinska Institutet; []
   Keywords : steroid hydroxylases; cyclic AMP; gene regulation; steroidogenesis; adrenalcortex;

   Abstract : Optimal steroid hormone output from the adrenal cortex depends on the peptide hormone ACTH which elicits its effect by increasing the intracellular levels of the second messenger cAMP, and a subsequent activation of the cAMP-dependent protein kinase. An important aspect of ACTH action is the ability of this hormone to increase transcription of a group of genes that encodes the steroid hydroxylases, enzymes that catalyze the conversion of cholesterol to biologically active steroids. READ MORE

4. 22. Adenosine A2A and ATP receptors in PC12 cells

   Author : Giulia Arslan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : PC12 cells; A2A receptors; ATP receptors; NGF; MAPK; Hypoxia; Cyclic AMP;

   Abstract : PC12 cells, originally isolated from a rat pheochromocytoma, are widely used to study receptor pharmacology and nerve cell differentiation. They are the neoplastic counterpart of adrenal chromaffin cells, but upon treatment with NGF they acquire a neuronal phenotype. READ MORE

5. 23. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming

   Author : Stephan Glund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : AMP-activated protein kinase; interleukin-6; exercise; glucose metabolism; lipid metabolism; adaptation to exercise.;

   Abstract : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. READ MORE

6. 24. Studies on the mechanism for natural killer cell cytotoxicity and its regulation

   Author : Lin-Sheng Xiao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : natural killer cell; nitric oxide; cytotoxicity; nitric oxide synthase; cyclic GMP; cyclic AMP; immunol regulation;

   Abstract : Since the proposed perforin-granzymes exocytosis can not sufficiently account for NK cell mediated cytolysis, the existence of a new and yet unknown mechanism for induction of the damage to targets by NK cells has been suggested. Our data illustrates that NK cell oncolytic activity has a requirement for L-arginine. READ MORE

7. 25. Adenosine action on platelets : pharmacological and functional studies in human platelets in vitro

   Author : Ulla Söderbäck; Karolinska Institutet; Karolinska Institutet; []
   Keywords : adenosine; adenosine analogs; methylxanthines; cyclic AMP; ADP; dipyridamole; platelet-rich plasma; whole blood aggregatron; human. Ulla SöderbäckAdenosine action on platelets. Pharmacological and functional studies in human pl;

   Abstract : The endogenous purine adenosine (ADO) is known to inhibit platelet aggregation in vitro through increased platelet levels of cyclic AMP. This effect is ADO-A2-receptor-mediated through stimulation of membrane adenylyl cyclase. READ MORE