Search for dissertations about: "APC-resistance"

Showing result 1 - 5 of 15 swedish dissertations containing the word APC-resistance.

  2. 1. Resistance to activated protein C a novel risk factor for venous thrombosis

    Author : Peter Svensson; Malmö Klinisk koagulationsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APC resistance; mutation; venous thrombosis; blood coagulation; Protein C; factor V; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : Activated protein C resistance (APC resistance) is the most common hereditary condition associated with venous thrombosis. The syndrome known as APC resistance is perfectly linked to a mutation in the gene coding coagulation FV (FV:Q506) mutation changing Arg 506 to Gln in the APC cleavage site. READ MORE

  4. 2. Risk Estimation and Prediction of Preeclampsia, IUGR, and Thrombosis in Pregnancy

    Author : Pelle Lindqvist; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; andrology; Obstetrics; Thrombosis; Smoking; Risk estimation; Risk; Pregnancy; Preeclampsia; IUGR; Evolution; Fetal loss; Abortion; APC resistance; reproduction; Obstetrik; sexuality; sexualitet; reproduktion; andrologi; gynekologi;

    Abstract : The aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. READ MORE

  5. 3. Pro- and anticoagulant mechanisms in coronary artery disease. Clinical studies on factor VII and resistance to activated protein C

    Author : Johan Holm; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein C; Factor VII; blood coagulation; myocardial infarction; APC resistance; Cardiovascular system; Kardiovaskulära systemet; warfarin;

    Abstract : The triggering mechanism in myocardial infarction (MI) and unstable angina involves coronary thrombus formation following plaque rupture. Coagulation is initiated by tissue factor that activates factor VII (FVII), and is inhibited by protein C and its co-factor protein S. READ MORE

  6. 4. Structural and functional studies of factor V in health and disease

    Author : Mårten Steen; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; APC resistance and hemophilia; thrombosis; factor VIII; coagulation; factor V;

    Abstract : The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. READ MORE

  7. 5. Effects of combined oral contraceptives on hemostasis and biochemical risk indicators for venous thromboembolism and atherothrombosis

    Author : Marianne van Rooijen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Combined oral contraceptives; emergency contraception; menstrual cycle; ethinylestradiol; levonorgestrel; desogestrel; lipoproteins; hemostasis; risk indicators; APC resistance; SHBG;

    Abstract : Combined oral contraceptives (COCs) are one of the most common contraceptive methods in the world. Already a few years after their introduction, in the early 1960s, case reports were published showing associations between use of COCs and venous and arterial thromboembolism. READ MORE