Search for dissertations about: "APOEε4"

Showing result 1 - 5 of 6 swedish dissertations containing the word APOEε4.

  2. 1. Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : results from the OmegAD study

    Author : Yvonne Freund-Levi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; progressive neurodegenerative disease; omega-3 fatty acid n-3 FA docosahexaenoic acid; DHA; eicosapentatenoic acid; EPA; linoleic acid; LA; acetylcholinesterase inhibitors; AChEI; Minimental State Examination; MMSE; ADAS-cog; Clinical Dementia Rating scale; CDR; Neuropsychiatric Inventory; NPI; Montgomery Åsberg Depression Rating scale; MADRS; Disability Assessment for Dementia; DAD; Care givers burden CGB; APOEε4; hs-CRP; IL-6; TNF-α and sIL-RII; Aβ42; T-tau and P-tau; weight; Body Mass Index; BMI.;

    Abstract : Alzheimer's disease (AD) is a major public health concern in all countries with an increasing prevalence. It is expected to quadruple by the year 2047. READ MORE

  4. 2. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology

    Author : Anna Edlund; Henrietta Nielsen; William Rebeck; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; insulin; metabolism; Amyloid precursor protein APP ; Fe65; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. READ MORE

  5. 3. Hormones, biomarkers, genetics and prognostication of patients suffering severe traumatic brain injury

    Author : Zandra Olivecrona; Lars-Owe Koskinen; Elisabeth Ronne-Engström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokirurgi; Neurosurgery;

    Abstract : Severe traumatic brain injury (sTBI) is a significant cause of mortality and mobidity worldwide. In Umeå University Hospital, at the department of Neurosurgery, patients with sTBI are treated by the Lund concept, which can be characterized as an intracranial pressure (ICP) targeted therapy. READ MORE

  6. 4. Diagnosis and monitoring of sport-related concussion

    Author : Sanna Neselius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; mild traumatic brain injury; sport-related concussion; concussion;

    Abstract : Background: Concussions are one of the most common sport-related injuries and it is known that they cause axonal and glial damage, and that there are risks for long-term effects. The aims of this thesis were to find possible methods, which may help clinicians to diagnose and monitor mild traumatic brain injury (TBI), analyse the APOEε4 allele genotype that has been associated with poor outcome after TBI and evaluate the relationship between neuropsychological assessment and brain injury biomarkers in the cerebrospinal fluid (CSF). READ MORE

  7. 5. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins

    Author : Tobias Mothes; Anna Erlandsson; Martin Ingelsson; Linn Streubel-Gallasch; Maria Grazia Spillantini; Uppsala universitet; []
    Keywords : Alzheimer’s disease; Parkinson’s disease; tauopathies; astrocyte; microglia; neuron; tau; amyloid-β; α-synuclein; accumulation; degradation; inflammation; spreading; seeding.; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. READ MORE