Search for dissertations about: "APS 1"

Showing result 1 - 5 of 30 swedish dissertations containing the words APS 1.

2. 1. Immunological Studies using Human and Canine Model Disorders

   Author : Kerstin M. Ahlgren; Anna Lobell; Olle Kämpe; Kerstin Lindblad-Toh; Roland Jonsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; T cell; T helper cell; B cell; Autoantibodies; Interferon; Interleukin; Dogs; APS-1; Candida albicans; fungus; Immunologi; Immunology; Medicin; Medicine;

   Abstract : The studies presented in this thesis focus on human and canine models for autoimmune disease, with the main aim to gain new knowledge about disease mechanisms and to further evaluate the dog as a model for autoimmune disease. Autoimmune Polyendocrine Syndrome type 1 (APS-1) is a hereditary human multiorgan disease caused by mutations in the autoimmune regulator (AIRE) gene. READ MORE

4. 2. Fine and Ultrafine Particles from Combustion Sources - Investigations with In-situ Techniques

   Author : Joakim Pagels; Ergonomi och aerosolteknologi; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; pollution control; Environmental technology; Teknik; Technological sciences; Indoor Air; In-Situ Measurement; Biomass Combustion; Morphology; Hygroscopic Growth; Volatility; TDMA; APS; ELPI; Respiratory Deposition; Fine Particles; Miljöteknik; kontroll av utsläpp; Ultrafine Particles;

   Abstract : Fine airborne particles are associated with adverse health effects in the human population. The aim of this research was to develop and evaluate methods for in-situ characterisation of fine and ultrafine particles and to determine their deposition in the human airways. READ MORE

5. 3. Pteridine dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1

   Author : Olov Ekwall; Uppsala universitet; []
   Keywords : Medical sciences; APS I; alopecia; autoantigen; cDNA; malabsorption; phenylalanine hydroxylase; pteridine; tryptophan hydroxylase; tyrosine hydroxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : Autoimmune polyendocrine syndrome type I (APS) is a monogenous, recessively inherited disease characterised by endocrine and non-endocrine autoimmune manifestations. One fifth of APS I patients suffer from periodic intestinal dysfunction with varying degrees of malabsorbtion, steatorrhea and constipation. READ MORE

6. 4. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

   Author : Annika Söderbergh; Uppsala universitet; []
   Keywords : Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). READ MORE

7. 5. Clinical and experimental studies of organ-specific autoimmune diseases : With special reference to Addison's disease and autoimmune hepatitis : by Gennet Gebre-Medhin

   Author : Gennet Gebre-Medhin; Uppsala universitet; []
   Keywords : Medical sciences; Addison s Disease; replacement therapy; DHEA; autoimmune hepatitis; APS I; autoantigen; cytochrome P4501A2; aromatic L-amino acid decarboxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : Organ-specific autoimmunity constitutes a large health problem, where both the clinical management and our understanding of the pathogenetic mechanisms need to improve. Women with Addison's disease have abnormally low levels of dehydroepiandrosterone (DHEA), its sulphate ester (DHEA-S) and androgens relative to age, and many patients complain of physical and mental fatigue and low stress tolerance. READ MORE