Search for dissertations about: "ARF"
Showing result 1 - 5 of 25 swedish dissertations containing the word ARF.
-
1. Dissecting Phenotypic Variation in Pigmentation using Forward and Reverse Genetics
Abstract : Coat color and patterning phenotypes have been extensively studied as a model for advancing our understanding of the relationship between genetic and phenotypic variation. In this thesis, genes of relevance for pigment cell biology were investigated. The dissertation is divided in two parts. READ MORE
-
2. Tumor biological aspects of the mucin-like glycoprotein CD43
Abstract : Cancer cells overexpress aberrant forms and amounts of mucins, which contribute to tumor development by regulating cell growth, survival, adhesion, invasion and immune responses. CD43, a type I transmembrane protein, is a mucin-like molecule expressed under normal physiological conditions by most hematopoietic cell types. READ MORE
-
3. Of Mice and MYC : Modelling Medulloblastoma
Abstract : Brain tumours are the leading cause of cancer-related paediatric deaths, with medulloblastoma (MB) being the most common malignant paediatric brain tumour. MB is stratified into four major subgroups – WNT, SHH, Group 3, and Group 4, nomenclature defined by key pathways and drivers involved within each subgroup. READ MORE
-
4. Germline CDKN2A/ARF alterations in human melanoma
Abstract : Approximately 10% of cases of human cutaneous malignant melanoma (CMM) have been estimated to occur in individuals with a familial predisposition, frequently in association with dysplastic nevus syndrome (DNS). The genetics of familial melanoma is complex and heterogeneous. To date only two melanoma predisposing genes have been identified. READ MORE
-
5. Molecular changes in the tumour suppressor genes p53 and CDKN2A/ARF in human urinary bladder cancer
Abstract : Urinary bladder neoplasm is the ninth most common cancer in Europe and the United States. The incidence in Sweden is approximately 32 for men and 9 for women per 105 subjects and year and almost all cases are transitional cell carcinoma (TCC). READ MORE