Search for dissertations about: "ASBT"

Found 5 swedish dissertations containing the word ASBT.

  2. 1. Bile Acid Induced Diarrhoea Pathophysiological and Clinical Aspects

    Author : Antal Bajor; Göteborgs universitet; []
    Keywords : Diarrhoea; bile acid transport; bile acid synthesis; 75SeHCAT reproducibility; C4; budesonide; collagenous colitis; in vitro; malabsorption; ASBT; intestinal secretion; potential difference; manometry;

    Abstract : A common cause for referral to gastroenterologists is chronic watery diarrhoea. Approximately 40% of these patients have idiopathic bile acid malabsorption (BAM) ? a condition with unknown aetiology. The 75SeHCAT test, which correlates inversely with faecal excretion and hepatic synthesis of bile acids, is used to diagnose BAM. READ MORE

  4. 2. Modulation of bile acid and cholesterol metabolism in health and disease

    Author : Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

    Abstract : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. READ MORE

  5. 3. Studies on the hormonal regulation of bile acid synthesis

    Author : Thomas Lundåsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The maintenance of a normal turnover of cholesterol is of vital importance, and disturbances of cholesterol metabolism may result in several important disease conditions. The major route for the elimination of cholesterol from the body is by hepatic secretion of cholesterol and bile acids (BAs) into the bile for subsequent fecal excretion. READ MORE

  6. 4. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

    Author : Samer Al-Dury; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

    Abstract : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. READ MORE

  7. 5. Studies on cholesterol and lipoprotein metabolism : emphasis on diabetes and sugar

    Author : Johanna Apro; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol has important functions in the body; as a precursor in the synthesis of steroid hormones and bile acids (BAs), and as a component of cellular membranes. However, an elevated level of plasma cholesterol, transported in low density lipoprotein (LDL) particles, is one of the major risk factors and causes for cardiovascular disease. READ MORE