Search for dissertations about: "ASK1"

Found 5 swedish dissertations containing the word ASK1.

  2. 1. Signaling mechanisms underlying neural stem cell differentiation. Implications of BMPs, retinoids, and MAP kinases

    Author : Roland Faigle; Göteborgs universitet; []
    Keywords : neural stem cells; differentiation; BMP; ASK1; p38 MAP kinase; CNTF; retinoic acid;

    Abstract : Introduction: Neural stem cells are proliferating cells, derived from the nervous system with the ability to give rise to neurons, astrocytes, and oligodendrocytes. The molecular events and signaling pathways regulating neural stem cell differentiation are largely unknown. READ MORE

  4. 2. Gene therapy of neuroblastoma

    Author : Yvonne Arvidsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Abstract : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. READ MORE

  5. 3. Directing stem cells and progenitors towards neuronal differentiation - implications for experimental therapies for Parkinson's disease

    Author : Anke Brederlau; Göteborgs universitet; []
    Keywords : stem cells; Parkinson s disease; progenitors; BMP; ASK1; dopamine;

    Abstract : The insight that stem- and progenitor-cells contribute to replacement of nerve cells in the adult central nervous system is the basis of modern therapies for structural brain repair. Their goal is to protect, support and stimulate endogenous stem cells in areas affected by disease and to replace lost cells by transplanting in vitro generated, tailored nerve cells. READ MORE

  6. 4. Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors

    Author : Muna Elmi; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: In the central nervous system of several species, including humans, neurogenesis per?sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic areas are proliferating cells, which can differentiate to neurons, astrocytes, and oligodendrocytes. READ MORE

  7. 5. From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease

    Author : Susanne Akterin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epidemiological studies have provided evidence that high cholesterol levels in midlife and lack of antioxidants could render people more susceptible to develop AD. The aim of this thesis project was to get a more profound view of how cholesterol and oxidative stress could modify the development of Alzheimer s disease (AD) on the molecular level, by studying mechanisms of signal transduction. READ MORE