Search for dissertations about: "ASP .NET"

Showing result 16 - 20 of 35 swedish dissertations containing the words ASP .NET.

  2. 16. Structural enzymology of the biosynthesis of polyketide antibiotics

    Author : Anna Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-ray crystallography; anthracycline; polyketide; Streptomyces; S-adenosyl-Lmethionine; methyltransferase; hydroxylase; aldol-condensation.;

    Abstract : Anthracyclines are an important group of aromatic antibiotics that exhibit antitumour activity, which makes them useful in treatment of various cancers. They are synthesised in the polyketide biosynthetic pathway as secondary metabolites by different Streptomyces species. READ MORE

  4. 17. Formyl-coenzyme : a transferase, structure and enzymatic mechanism

    Author : Stefano Ricagno; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-ray crystallography; oxalate degradation; Oxalobacter; CoA transferase; interlocked dimer; anhydride.;

    Abstract : Background: Formyl-CoA transferase (Frc) is the first enzyme in a two enzyme pathway responsible for oxalate degradation in Oxalobacter formigenes. This bacterium is a constitutive part of human intestinal flora. Its role as an oxalate scavenger is very important, reports have shown a strong connection between the disappearance of 0. READ MORE

  5. 18. Molecular mechanisms in amyloid fibril formation

    Author : Waltteri Hosia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties in terms of charge distribution, hydrophobicity and secondary structure, yet they differ in their aggregation propensities. READ MORE

  6. 19. The type-I acyl-CoA thioesterase/acyltransferase gene family : linking structure to function

    Author : James O'Byrne; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type-I acyl-CoA thioesterase acyltransferase gene family; structure function relationship; nueleophilic elbow; esterase transferase activity;

    Abstract : Acyl-CoA thioesterases hydrolyse acyl-CoAs to non-esterified fatty acids and coenzyme A (CoASH), thereby regulating intracellular levels of these compounds. We have recently identified and initiated characterisation of a novel, unique gene family of acyl-CoA thioesterases/acyltransferases, called the Type-I acyl-CoA thioesterase/acyltransferase gene family. READ MORE

  7. 20. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Author : Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Insulin-like growth factor;

    Abstract : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. READ MORE