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Showing result 1 - 5 of 8 swedish dissertations matching the above criteria.

  2. 1. Diagnostic and prognostic value of the AST/ALT ratio as an indicator of cirrhosis in chronic liver disease

    Author : Helena Nyblom; Göteborgs universitet; []
    Keywords : alcohol dependence; alcohol-related liver disease; AST ALT ratio; cirrhosis; cholangiocarcinoma; primary biliary cirrhosis; primary sclerosing cholangitis;

    Abstract : .... READ MORE

  4. 2. Incidence, predictors and biomarkers for antiretroviral and/or anti-tuberculosis drugs induced liver injury

    Author : Getnet Yimer Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Anti-tuberculosis and/or antiretroviral drugs induced liver injury (DILI) is a major challenge when managing TB and/or HIV patients. The aims of this thesis were to identify incidence, risk factors, and management of DILI among 4 different treatment groups namely; HIV positive individuals with no TB co-infection and had a CD4 count of < 200 cells/μl (taking ARV drugs alone = arm 1), TB-HIV co-infected patients with a CD4 count of < 200 cells/μl (taking both anti-TB and ARV drugs = arm 2), TB-HIV co-infected patients with a CD4 count of > 200 cells/μl (taking anti-TB alone = arm 3), HIV negative TB patients (taking anti-TB alone = arm 4). READ MORE

  5. 3. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

    Author : Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. READ MORE

  6. 4. Ethyl glucuronide : a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results

    Author : Helen Dahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In recent years, there has been a growing interest in various biochemical markers for detecting acute and chronic alcohol consumption. Biochemical markers for acute and chronic drinking play important roles in detecting alcohol use, abuse and dependence in hospital settings, work place settings, traffic medicine and in forensic toxicology examinations. READ MORE

  7. 5. Metabolic and pharmacokinetic study to enhance busulphan therapeutic efficacy

    Author : Fadwa Benkessou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Busulphan (Bu) is an alkylating agent used in high-doses as part of the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). HSCT is a curative treatment for hematological malignancies and other disorders. Bu can be administered by oral or intravenous route. READ MORE