Search for dissertations about: "AT- I cardiomyocytes"

Showing result 1 - 5 of 23 swedish dissertations containing the words AT- I cardiomyocytes.

2. 1. Cardiomyocyte Cell Cycle, Renewal and Isolation

   Author : Stuart Walsh; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; binucleation; Cardiomyocytes; surface marker; troponin-T; mitosis; microarray; cell cycle; FACS;

   Abstract : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. READ MORE

4. 2. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Author : Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Abstract : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. READ MORE

5. 3. Cell shape determines gene expression in cardiomyocytes

   Author : Payam Haftbaradaran Esfahani; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The fundamental biological processes involve sensing biophysical stress, strain and forces along with conversion of these stimuli into chemical signals. These processes are linked to the atrophic and hypertrophic responses. Deficiencies in these biological processes are associated with different diseases, particularly in the circulation system. READ MORE

6. 4. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

   Author : Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
   Keywords : TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

   Abstract : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. READ MORE

7. 5. Molecular pharmacology of amiodarone

   Author : Viktor Drvota; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Amiodarone; thyroid hormone receptors; B-adrenergic receptors; AT-1 cardiomyocytes; Western blot; solution hybridization; Fura-2; Langendorff heart; mouse; guinea pig;

   Abstract : Amiodarone (Am) is a potent class III antiarrhythmic drug. Its use is limited due to serious side effects and it was therefore used only when other therapeutic interventions proved to be ineffective. READ MORE