Search for dissertations about: "AT1R"
Showing result 1 - 5 of 9 swedish dissertations containing the word AT1R.
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1. Helicobacter pylori associated effects on inflammatory radical formation and angiotensin II receptors in the stomach
Abstract : Helicobacter pylori infection of the stomach always results in mucosal inflammation and a marked systemic immune response. Despite the profound host defence reactions the bacterium avoids elimination and persists in the mucosa. This results in chronic inflammation and an increased risk for peptic ulcers and adenocarcinoma. READ MORE
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2. Canonical and noncanonical transducers for calcium signaling : role of Na,K-ATPase and angiotensin receptor
Abstract : Calcium (Ca2+) is the most universal and versatile signal in the cell. This versatility is based on the speed, amplitude and spatio-temporal patterning of the Ca2+ events. The inositol 1,4,5-trisphosphate receptor (IP3R) is one of the main Ca2+ channels responsible for the Ca2+ release from the intracellular stores. READ MORE
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3. On angiotensin II receptor type 2 receptors in the small intestine
Abstract : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. READ MORE
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4. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor
Abstract : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. READ MORE
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5. Studies on molecular mechanisms in calcium signaling and cellular energy consumption
Abstract : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. READ MORE