Search for dissertations about: "ATC"

Showing result 1 - 5 of 26 swedish dissertations containing the word ATC.

  2. 1. Activity and Regulation of Telomerase in Malignant Cells

    Author : Anna Lindkvist; Ylva Paulsson-Karlsson; Göran Roos; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; apoptosis; ATC; c-Myc; drug sensitivity; ESCC; hTERT; hypoxia; IFN; MM; neuroblastoma; p53; telomerase; TGF-β; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : An important step in tumorgenesis is the acquisition of cellular immortality. Tumor cells accomplish this by activating the enzyme telomerase, and thereby avoiding replicative senescence. The aim of this thesis was to study the activity and regulation of telomerase in a panel of malignant cell types. READ MORE

  4. 2. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

    Author : Naveen Ravi; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic thyroid cancer; copy number alterations; somatic mutations; mutational signatures; DNA methylation analysis; Gene expression analysis;

    Abstract : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. READ MORE

  5. 3. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Author : Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Abstract : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). READ MORE

  6. 4. Time to Plan : How to support everyday planning in adolescents with intellectual disability

    Author : Lisa Palmqvist; Henrik Danielsson; Arne Jönsson; Jerker Rönnberg; Christopher Jarrold; Linköpings universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; intellectual disability; everyday planning; executive functions; assistive technologies for cognition; intellektuell funktionsnedsättning; vardagsplanering; exekutiva funktioner; kognitionshjälpmedel;

    Abstract : Children and adolescents with intellectual disability (ID) have difficulties in executive functioning and when coping with everyday planning tasks. However, the literature cannot explain whether individuals with ID perform according to their developmental level or not. READ MORE

  7. 5. Human-automation teamwork : Current practices and future directions in air traffic control

    Author : Åsa Svensson; Jonas Lundberg; Camilla Forsell; Niklas Rönnberg; Henrik Artman; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This dissertation explores the topic of human-automation teamwork in Air Traffic Control (ATC). ATC is a high stakes environment where complex automation is being introduced while the human operator has the legal responsibility. READ MORE