Search for dissertations about: "ATTR"

Showing result 1 - 5 of 14 swedish dissertations containing the word ATTR.

  2. 1. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

    Author : Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). READ MORE

  4. 2. Cardiac function in hereditary transthyretin amyloidosis : an echocardiographic study

    Author : Sandra Arvidsson; Per Lindqvist; Eva Nylander; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid; echocardiography; ECG; HCM; fibril type; strain; ATTR; cardiomyopathy; speckle tracking;

    Abstract : Background: Hereditary transthyretin amyloidosis (ATTR) is a lethal disease in which misfolded transthyretin (TTR) proteins accumulate as insoluble aggregates in tissues throughout the body. A common mutation is the exchange of valine to methionine at place 30 (TTR V30M), a form endemically found in the northern parts of Sweden. READ MORE

  5. 3. Selection of transthyretin amyloid inhibitors

    Author : Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). READ MORE

  6. 4. Hereditary transthyretin amyloidosis (ATTR V30M) : from genes to genealogy

    Author : Nina Norgren; Ole Suhr; Alda Sousa; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hereditary transthyretin amyloidosis; Familial amyloid polyneuropathy; transthyretin; genealogy; founder effect; miRNA; allele-specific expression; gene expression; liver; medicin; Medicine;

    Abstract : Background: Hereditary transthyretin amyloidosis is an autosomal dominant disease with a reduced penetrance. The most common mutation in Sweden is the V30M mutation in the transthyretin gene. Clustering areas of the disease can be found in Northern Sweden, Portugal, Brazil and Japan, although sporadic cases exist worldwide. READ MORE

  7. 5. Two Types of Fibrils in ATTR Amyloidosis : Implications for Clinical Phenotype and Treatment Outcome

    Author : Elisabet Ihse; Per Westermark; Per Hammarström; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; transthyretin; familial amyloidotic polyneuropathy; TTRV30M; non-TTRV30M; wild-type; liver transplantation; cardiomyopathy; fibril composition; Biokemi; Biochemistry; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Experimentell patologi; Experimental Pathology; Medical Biochemistry; Medicinsk biokemi; Molecular Biology; Molekylärbiologi; Pathology; Patologi;

    Abstract : Systemic amyloidoses are a group of lethal diseases where proteins aggregate into fibrillar structures, called amyloid fibrils, that deposits throughout the body. Transthyretin (TTR) causes one type of amyloidosis, in which the aggregates mainly infiltrate nervous and cardiac tissue. READ MORE