Search for dissertations about: "Abeta"
Showing result 1 - 5 of 42 swedish dissertations containing the word Abeta.
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1. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors
Abstract : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. READ MORE
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2. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease
Abstract : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. READ MORE
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3. Islet Amyloid Polypeptide: Interaction with Amyloid Beta, Alpha-Synuclein and BRICHOS
Abstract : Amyloid, the congophilic deposits of misfolded protein, are pathological hallmarks of many common diseases, among others, Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D). Amyloid beta (Aβ) forms senile plaques in AD, alpha-synuclein (aSyn) forms Lewy bodies and Lewy neurites in PD, islet amyloid polypeptide (IAPP) forms islet amyloid in T2D. READ MORE
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4. Alzheimer disease : studies on Abeta and gamma-secretase in human brain
Abstract : Alzheimer disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia. One hallmark of the disease is the extracellular deposition of amyloid beta-peptide (Abeta) into senile plaques in the brain. Biochemical and genetic studies reveal Abeta as a key player in AD pathogenesis. READ MORE
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5. Genetic variation in genes involved in Abeta-degradation in Alzheimer disease
Abstract : Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly people and is increasing in prevalence in industrialized societies from 1 to 3 % in 60-65 year-olds to as much as 50 % by age 95. This disease is complex. Multiple genes are involved, and they potentially affect each other. READ MORE