Search for dissertations about: "Abeta"

Showing result 1 - 5 of 41 swedish dissertations containing the word Abeta.

  1. 1. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors

    University dissertation from Lund University, Faculty of Science, Department of Biochemistry and Structural Biology

    Author : Xiaoting Yang; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; Abeta; aggregation; kinetics; secondary nucleation;

    Abstract : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. READ MORE

  2. 2. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marie Oskarsson; Gunilla Westermark; Mikael Oliveberg; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; type 2 diabetes; Alzheimer disease; BRICHOS; heparan sulfate; islet amyloid; amyloid plaques; seeding; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. READ MORE

  3. 3. Alzheimer disease : Studies on Abeta and gamma-secretase in human brain

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Hedvig Welander; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Alzheimer disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia. One hallmark of the disease is the extracellular deposition of amyloid beta-peptide (Abeta) into senile plaques in the brain. Biochemical and genetic studies reveal Abeta as a key player in AD pathogenesis. READ MORE

  4. 4. Genetic variation in genes involved in Abeta-degradation in Alzheimer disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Mia Blomqvist; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer disease; SNPs; genotyping; association study; haplotype; linkage disequilibrium; association mapping;

    Abstract : Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly people and is increasing in prevalence in industrialized societies from 1 to 3 % in 60-65 year-olds to as much as 50 % by age 95. This disease is complex. Multiple genes are involved, and they potentially affect each other. READ MORE

  5. 5. Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer’s disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

    Author : Erik Portelius; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Cerebrospinal fluid; Immunoprecipitation; Mass spectrometry; beta-amyloid;

    Abstract : Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage disease. READ MORE